In Vitro Fertilization Clinical Trial
Official title:
Comparing the Efficacy of Urinary and Recombinant hCG on Oocyte Maturity for Ovulation Induction in Assisted Reproductive Techniques: a Randomized Clinical Trial
Verified date | October 2010 |
Source | Royan Institute |
Contact | n/a |
Is FDA regulated | No |
Health authority | Iran: Ethics CommitteeIran: Ministry of Health |
Study type | Interventional |
This study is a prospective randomized clinical trial to compare the efficacy of the urinary and recombinant hCG on oocyte quality for ovulation induction in women undergoing IVF/ICSI.
Status | Completed |
Enrollment | 180 |
Est. completion date | June 2013 |
Est. primary completion date | September 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 20 Years to 37 Years |
Eligibility |
Inclusion Criteria: - Indication for IVF/ICSI and Long Protocol ovarian stimulation - Age 20-37 - Body mass index (BMI) = 30 kg/m2 - Regular menstrual cycles of 25-35 days - Tubal or male factor - Existence of both ovary and normal uterine cavity - Basal FSH=10 - Physical health Exclusion Criteria: - Poly Cystic Ovarian Syndrome patients - Contraindications of gonadotropins administration - Poor response to ovulation induction in recent cycle |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Iran, Islamic Republic of | Royan Institute | Tehran |
Lead Sponsor | Collaborator |
---|---|
Royan Institute |
Iran, Islamic Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of mature oocytes | evaluation the effect of recombinant hcg on number of oocytes up to 1 hour after oocytes retrieval | Up to1 hour after oocyte retrieval | Yes |
Secondary | number of retrieved oocytes per number of aspirated follicles proportion | Evaluation the effect of recombinant hCG to retrieve oocytes per number of aspirated follicles proportion | up to 1 hour after oocyte retrieval | Yes |
Secondary | fertilization rate | Evaluation the effect of recombinant hCG on fertilization rate in 1 day after oocyte retrieval | in 1 day after oocyte retrieval | Yes |
Secondary | implantation rate | Evaluation the effect of recombinant hCG on implantation rate 4 weeks after embryo transfer | 4 weeks after embryo transfer | Yes |
Secondary | OHSS occurrence rate will be compared between three groups | Evaluation the effect of recombinant hCG on OHSS occurrence rate will be compared between three groups | from embryo transfer day up to pregnancy test | Yes |
Secondary | chemical pregnancy rates | Evaluation the effect of recombinant hCG on chemical pregnancy rates 2 weeks after embryo transfer | 2 weeks after embryo transfer | Yes |
Secondary | clinical pregnancy rates | Evaluation the effect of recombinant hCG on clinical pregnancy rates 4 weeks after embryo transfer | 4 weeks after embryo transfer | Yes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00696878 -
Corifollitropin Alfa in Participants Undergoing Repeated Controlled Ovarian Stimulation (COS) Cycles Using a Multiple Dose Gonadatropin Releasing Hormone (GnRH) Antagonist Protocol (Study 38825)(P05714)
|
Phase 3 | |
Recruiting |
NCT04122729 -
N680S Polymorphism of the FSHR Gene and Its Relationship With the Type of Gonadotropin Used in COS
|
||
Not yet recruiting |
NCT02534857 -
A Study Comparing a Shorter Exposure of Oocyte to Spermatozoa Versus a Standard Incubation on the Live Birth Rate of In-vitro Fertilization Treatment
|
N/A | |
Recruiting |
NCT01406600 -
Optimal rhCG(Ovidrel®) Dose in Poor Responder During IVF and ICSI Cycles
|
N/A | |
Completed |
NCT01406028 -
Does Emotional Support Decrease In Vitro Fertilization Stress?
|
N/A | |
Withdrawn |
NCT00541892 -
Sibling Oocyte Study of Medium for In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) With no Human Serum Albumine
|
Phase 2 | |
Completed |
NCT00708383 -
in Vitro Fertilization (IVF) Media Protein and Live Birth Rates
|
N/A | |
Completed |
NCT03627533 -
The Differences of Oocyte Maturation, Granulosa Cell Apoptosis Index Between Electroacupuncture And Sham Groups IVF
|
N/A | |
Recruiting |
NCT04160611 -
What Amount of Stress is Enough for a Successful Conception?
|
Phase 3 | |
Suspended |
NCT01600794 -
To Evaluate The Anrogens and Ovary Function in In Vitro Fertilization
|
N/A | |
Terminated |
NCT00866008 -
A Study of the Effects of a Novel Ovarian Stimulation Regimen on Embryo Aneuploidy Rates in In Vitro Fertilization (IVF)
|
Phase 4 | |
Recruiting |
NCT04082650 -
Vitamin D and Pregnancy Outcome in PCOS Patients
|
N/A | |
Recruiting |
NCT03758833 -
eSET or eDET Associated to PGT in IVF
|
N/A | |
Not yet recruiting |
NCT04407871 -
Acupuncture and Chinese Herbal Medicine to Improve Live Birth Rate of in Vitro Fertilization (IVFAct)
|
N/A | |
Recruiting |
NCT03345030 -
The Role of DNA Damage of Granulosa Cell on Oocyte Quality and in Vitro Fertilization Outcome
|
N/A | |
Not yet recruiting |
NCT06367985 -
CAPA-IVM Culture With Low Oxygen Tension
|
N/A | |
Not yet recruiting |
NCT03090438 -
IVF Outcomes After Varicocele Repair
|
N/A | |
Terminated |
NCT01614067 -
Delayed Start to Ovarian Stimulation
|
Phase 4 | |
Completed |
NCT01343992 -
Bed Rest or no Bed Rest?
|
N/A | |
Completed |
NCT00557687 -
Prediction of Ovarian Response
|
N/A |