In Vitro Fertilization Clinical Trial
Official title:
Comparing the Efficacy of Urinary and Recombinant hCG on Oocyte Maturity for Ovulation Induction in Assisted Reproductive Techniques: a Randomized Clinical Trial
This study is a prospective randomized clinical trial to compare the efficacy of the urinary and recombinant hCG on oocyte quality for ovulation induction in women undergoing IVF/ICSI.
The study population comprised of all infertile patients aged 20-37 years which underwent of
in-vitro fertilization in royan institute, Tehran Iran.
In this study all patients were treated with a long stimulation protocol in which
GnRH-analogue (Buserelin subcutaneous, 0.5cc daily) was given as a pre-treatment and
recombinant FSH (rFSH) administration was started when pituitary desensitization was
confirmed. From the 7th day of stimulation in both groups, daily monitoring of follicle size
by ultrasound was performed and the dose of rFSH was adjusted according to the response of
each patient. When at least two follicles > 18 mm diameter were seen, ovulation was
triggered with hCG and patients allocated into three different study groups as per the
following:
1. Group A consisted of 60 women who received recombinant hCG(250 µg Ovitrelle)
2. Group B consisted of 60 women who received recombinant hCG(500 µg Ovitrelle)
3. Group C consisted of 60 patients received 10,000 IU urinary hCG Oocyte retrieval
performed about 34-36 hours after hCG administration and then oocytes were assessed for
nuclear maturity. Embryos transferred 2-3 days thereafter.
Data collection will be performed by using questionnaire to be filled as per the available
records and laboratory results. Data analysis will be done through descriptive and
perceptive statistical methods by using SPSS software version 16 for windows.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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