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Optimal rhCG(Ovidrel®) Dose in Poor Responder During IVF and ICSI Cycles

in Vitro Fertilization Clinical Trial

Official title:
Optimal rhCG(Ovidrel®) Dose for Final Oocyte Maturation Triggering in Poor Responder During IVF and ICSI Cycles

Clinical Trial Summary

Choriogonadotropin alfa (Ovidrel®) is a recombinant hCG (rhCG) preparation derived from genetically engineered Chinese hamster ovary cells, which is widely used for final oocyte maturation triggering in assisted reproductive technology (ART).Recombinant hCG has been investigated about its safety and efficacy comparing with urinary hCG, but still the optimal dose of rhCG is questionable. From former studies, there only have been proven that high dose of hCG can make ovarian hyperstimulation syndrome (OHSS) in usual condition. On the other hand, we hypothesize that high dose of hCG may improve oocyte maturity in poor responders who cannot easily provoke OHSS. Hence, this study will assess the comparative efficacy and safety of 250mcg and 500mcg of rhCG in ART treatment cycle.

Clinical Trial Description

Randomized prospective clinical study that compare the two doses of rhCG (250mcg vs. 500mcg). ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01406600
Study type Interventional
Source Seoul National University Hospital
Contact Kyung Eui Park, M.D.
Phone +82-2-2072-3529
Email kepark.md@gmail.com
Status Recruiting
Phase N/A
Start date September 2011
Completion date December 2013
View Details
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