In Vitro Fertilization Clinical Trial
Official title:
A Prospective Randomized Study Comparing Coasting by Withholding GnRH Agonist With GnRH Antagonist Administration in Patients at Risk for Severe OHSS
Ovarian hyperstimulation syndrome (OHSS) is the most serious complication of ovulation induction and is a life threatening iatrogenic complication. In patients with GnRH agonist protocol, both withdrawing GnRH agonist and GnRH antagonist administration are associated with a reduction in (E2) levels with subsequent decreasing the incidence and severity of OHSS. This work is to compare the clinical and endocrine outcome response of cycles in which GnRH agonist withdrawing with cycles in which the GnRH antagonist administration in patients at risk of severe OHSS.
Status | Recruiting |
Enrollment | 120 |
Est. completion date | December 2012 |
Est. primary completion date | June 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 20 Years to 38 Years |
Eligibility |
Inclusion Criteria: - the risk of ovarian hyperstimulation syndrome Exclusion Criteria: - allergic to GnRH antagonist |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Taiwan | Department of Obstetrics and Gynecology, Shin-Kong Wu Ho-Su Memerial Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
Shin Kong Wu Ho-Su Memorial Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | decreased levels of estradiol (E2) | one year | No | |
Primary | The days of coasting | The interval between the day of starting intervention and the day of hCG administration | one year | No |
Secondary | number of oocytes retrieved | one year | No | |
Secondary | pregnancy rate | one year | No | |
Secondary | the incidencess of OHSS | one year | No |
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