Impulsive Behavior Clinical Trial
Official title:
Measuring Cortical Dynamics of Inhibitory Control Before, During and After Transcranial Direct Current Stimulation (tDCS)
This study aims to use concurrent Transcranial Direct Current Stimulation (tDCS) and Magnetoencephalography (MEG) with measures of impulsivity to examine the neurobiological underpinnings of rapid response impulsivity (RRI) and how these can be modified using tDCS in healthy subjects.
Concurrent tDCS-MEG parallel arms single-blinded experimental design (right anodal v sham
tDCS) will be employed in this study. The study will be conducted at the University of
Nottingham, using a sample of student volunteers. This study aims to examine the influence of
anodal tDCS on beta-band and alpha-band oscillatory activities, using an anti-saccade task
administered before, during and after tDCS stimulation. It can potentially help understand
the neurobiological mechanisms underpinning rapid response impulsivity and how these can be
influenced by tDCS.
The research hypotheses are that (i) a generalised mechanism for top-down inhibitory control
will play a vital role, whereby prefrontal beta-band activity initiates alpha-band activity
for functional inhibition over the frontal eye fields and other areas in the neurocircuitry
involved in RRI; (ii) anodal tDCS (as opposed to sham) delivered over the right DLPFC will
enhance this mechanism; and (iii) there will be no significant correlations between measures
of self-report impulsivity and performance on the anti-saccade task and measures of
oscillatory activity.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03898336 -
Eat2beNICE Vitamins and Nutrients as Supplementation for Impulsivity, Irritability, and Compulsivity
|
N/A | |
| Terminated |
NCT03527550 -
Cognitive Control Training for Urgency in a Naturalistic Clinical Setting
|
N/A | |
| Recruiting |
NCT03218670 -
Your Health in On Click
|
N/A | |
| Not yet recruiting |
NCT04811807 -
Clinical Response of Impulsivity After Brain Stimulation in Parkinson's Disease
|
||
| Completed |
NCT02740582 -
Effects of Tolcapone on Decision Making and Alcohol Intake in Alcohol Users
|
Phase 2 | |
| Not yet recruiting |
NCT02595164 -
Common Decision Making Deficits in Suicidal Behaviors and Eating Disorders
|
N/A | |
| Recruiting |
NCT04960969 -
The Effects of Time-Restricted Eating Model
|
N/A | |
| Not yet recruiting |
NCT03498937 -
Effects of tDCS on Impulsiveness Among People Suffering From Borderline Personality Disorder
|
N/A | |
| Completed |
NCT03200873 -
Effects of rTMS on Impulsivity and Empathy
|
N/A | |
| Terminated |
NCT03838484 -
Effects of Transdermal Nicotine on Response Inhibition to Emotional Cues in Schizophrenia
|
N/A | |
| Completed |
NCT04290533 -
HD-tDCS Over the dACC in High Trait Impulsivity
|
N/A | |
| Completed |
NCT05031559 -
Episodic Future Thinking and Compassion
|
N/A | |
| Completed |
NCT01158950 -
A Study of Neural Circuit Responses to Catechol-O-methyl Transferase (COMT) Inhibitors
|
N/A | |
| Recruiting |
NCT05875181 -
Examining the Impact of Transcranial Focused Ultrasound (tFUS) on Reward Neural Circuitry
|
N/A | |
| Not yet recruiting |
NCT05894980 -
How to Reduce Suicidal Thoughts and Impulsivity in Depression
|
N/A | |
| Not yet recruiting |
NCT03190681 -
Motivation and Methylphenidate
|
Early Phase 1 | |
| Completed |
NCT01805401 -
tDCS Applied to the OFC: Effects on Decision-Making and Impulse Control
|
N/A | |
| Completed |
NCT03006653 -
Understanding Daily Fluctuations in Self-Regulation
|
N/A | |
| Active, not recruiting |
NCT04785677 -
Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration
|
N/A | |
| Active, not recruiting |
NCT04848532 -
Problematic Decision-Making and Adolescent Weight Loss
|
N/A |