Impulsive Behavior Clinical Trial
Official title:
Measuring Cortical Dynamics of Inhibitory Control Before, During and After Transcranial Direct Current Stimulation (tDCS)
This study aims to use concurrent Transcranial Direct Current Stimulation (tDCS) and Magnetoencephalography (MEG) with measures of impulsivity to examine the neurobiological underpinnings of rapid response impulsivity (RRI) and how these can be modified using tDCS in healthy subjects.
Concurrent tDCS-MEG parallel arms single-blinded experimental design (right anodal v sham
tDCS) will be employed in this study. The study will be conducted at the University of
Nottingham, using a sample of student volunteers. This study aims to examine the influence of
anodal tDCS on beta-band and alpha-band oscillatory activities, using an anti-saccade task
administered before, during and after tDCS stimulation. It can potentially help understand
the neurobiological mechanisms underpinning rapid response impulsivity and how these can be
influenced by tDCS.
The research hypotheses are that (i) a generalised mechanism for top-down inhibitory control
will play a vital role, whereby prefrontal beta-band activity initiates alpha-band activity
for functional inhibition over the frontal eye fields and other areas in the neurocircuitry
involved in RRI; (ii) anodal tDCS (as opposed to sham) delivered over the right DLPFC will
enhance this mechanism; and (iii) there will be no significant correlations between measures
of self-report impulsivity and performance on the anti-saccade task and measures of
oscillatory activity.
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