Non-Invasive Measurement of SjvO2 Using Near Infrared Spectroscopy in Critically Ill Patients

Impaired Oxygen Delivery Clinical Trial

— NIRS-SCJVO2  

Official title:

Relationship Between Near Infrared Spectroscopy Jugular Venous Oxygen Saturation (SjvO2) and Central Venous Saturation of Oxygen (ScvO2) in Critically Ill Patients.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04624009
• Other study ID #: SjvO2 vs ScvO2 / HUG-DMA
• Status: Completed
• Start date: January 1, 2022
• Est. completion date: August 1, 2023

Study information

• Verified date: May 2022
• Source: University Hospital, Geneva
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

ScvO2 is an important parameter in the management of critically ill patient. The only way to measure it is to have an internal jugular or subclavian central venous catheter. With this trial, the investigators want to show a positive relationship between invasive ScvO2 measurement and noninvasive SjvO2 measurement with VO 100 medical device from Mespere LifeSciences, allowing the use of SjvO2 as a noninvasive surrogate of ScvO2 in critically ill patients.

Description:

ScvO2 measures central venous oxygen saturation level from veins draining the head and upper body while SvO2 measures mixed venous oxygen saturation from the lower and upper half of the body. ScvO2 is more conveniently measured and less risky than Sv02 measurement although a central venous catheter is needed. ScvO2 gives knowledge about the balance between the delivery of oxygen and oxygen consumption in the body. Interest in ScvO2 monitoring in anesthesia and critical care has been debated. However, ScvO2 is still recommended as a major hemodynamic target of early resuscitation of critically ill patients. Even if ScvO2 measurement is far less invasive than SvO2 measurement through pulmonary artery catheter, it is accompanied with morbidity.

VO 100 medical device from Mespere LifeSciences allows a non-invasive measurement of SjvO2 using the NIRS technique. Jugular venous oxygen saturation (SjvO2) is a measurement of the amount of oxygen left in the venous system after the brain has removed the oxygen that it needs.

On the same principle that a positive relationship between ScvO2 and SvO2 has been shown, what the investigators are trying to do is to show a positive relationship between SjvO2 and ScvO2 in order to possibly use in the future SjvO2 measured by VO 100 as a noninvasive surrogate of ScvO2.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 35
• Est. completion date: August 1, 2023
• Est. primary completion date: April 1, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• all ICU adult patients routinely equipped with a central venous catheter placed in internal jugular or subclavian vein allowing ScvO2 measurement from blood sampling.

The investigators will perform this study only on patients already equipped with an internal jugular CVC. In other words, the placement of the CVC is not conditioned by the study realization.

Exclusion Criteria:

• patients with CVC placed in another site than internal jugular vein.

Related Conditions & MeSH terms

• Critical Illness
• Critically Ill Patient
• Impaired Oxygen Delivery

Locations

Country	Name	City	State
Switzerland	University of Geneva	Geneva
Switzerland	Eduardo Schiffer	Veyrier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Geneva

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparison of venous oxygen saturation 1	Comparison of ScvO2 values from CVC blood sample and SjvO2 values from the VO 100 (% oxygen saturation)	On admission to the intensive care unit
Secondary	Comparison of venous oxygen saturation 2	Comparison of ScvO2 values from CVC blood sample and SjvO2 values from the VO 100 (% oxygen saturation)	3 days after admission into the intensive care unit
Secondary	Comparison of venous oxygen saturation 3	Comparison of ScvO2 values from CVC blood sample and SjvO2 values from the VO 100 (% oxygen saturation)	On admission to internal medicine ward