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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01549600
Other study ID # 2011063
Secondary ID
Status Completed
Phase N/A
First received March 6, 2012
Last updated October 27, 2014
Start date February 2012
Est. completion date May 2013

Study information

Verified date April 2014
Source Procter and Gamble
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

The Purpose of this study is to compare the effects of 2 types of dietary fiber, psyllium and microcrystalline cellulose (MCC), on glycemic measures in subjects with impaired fasting glucose.


Description:

This study will be conducted at a single study center. Approximately 40 subjects with pre-type 2 diabetes will be enrolled and randomized in this study.

This 22-week study consists of 3 periods: an 8-week treatment period (Visits 2-4), a 6-week washout period, and an 8-week treatment period (Visits 5-7).


Recruitment information / eligibility

Status Completed
Enrollment 18
Est. completion date May 2013
Est. primary completion date May 2013
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- be male or female,

- at least 18 years of age

- in generally good health for the pre-type 2 diabetes population;

- if female, be postmenopausal or if of child-bearing capacity agree to use an adequate form of contraception

- have not used any psyllium containing products within the past 3 months;

- be willing to refrain from taking any psyllium containing products during the study;

- be willing to maintain a lifestyle habits for the duration of the study;

- have a fasting serum glucose of 110 - 125 mg/dL

Exclusion Criteria:

- if female, are pregnant or nursing (lactating);

- have a history of diabetes (diagnosis) or is currently taking medications for diabetes

- participated in a clinical drug study or used investigational drug during the previous 30 days;

- have symptoms and signs suggestive of significant underlying disease, or acute onset of new symptoms and signs of major organ disease, that could become unstable during the trial requiring urgent medical intervention

- have evidence of or treatment history of malignancy within the previous 5 years;

- currently alcohol dependent;

- used anti-psychotics in the previous 3 months;

- used systemic steroidal agents within the last 30 days;

- had used oral or systemic antibiotics or any over-the-counter (OTC) bactericidal medication (eg, bismuth salts) within the last 30 days;

- has been taking any medication that may affect blood glucose or GI motility (eg, calcium channel blockers, beta blockers, antimuscarinics, salicylates etc.) for less than 30 days or 5 times the half life of the drug (need to be stable on the medication);

- have evidence of immunodeficiency including subjects currently taking systemic corticosteroids or immunosuppressive drugs

- have a major psychiatric disorder, including major depression, psychoses, alcohol or substance abuse within the past 2 years;

- has a known sensitivity or allergy to any components of study products, including psyllium and aspartame (see Section 3.5.3);

- were previously screened (ie, Visit 1 procedures) for participation in this study and failed to meet entry criteria;

- have difficulty swallowing

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
psyllium
1 level tablespoon (~ 5.1 g psyllium husk in the psyllium product) mixed with at least 8 ounces of water, taken twice daily
Microcrystalline Cellulose
1 level tablespoon (~ 1.18 g MCC in the MCC product) mixed with at least 8 ounces of water, taken twice a day

Locations

Country Name City State
United States Duke University Medical Center Durham North Carolina

Sponsors (2)

Lead Sponsor Collaborator
Procter and Gamble Duke University

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary fasting serum glucose mean change from baseline in fasting serum glucose at 8 weeks 8 weeks No
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