Clinical Trials Logo

Clinical Trial Summary

Background: One of the most frequent surgical operations in dentistry is the surgical extraction of the impacted mandibular third molar, which is accompanied by a sequelae of swelling, trismus, and pain. Various techniques have been employed to either prevent or reduce these postoperative outcomes. To the best of our knowledge, few clinical researchers have investigated the effect of local application of Alvogyl paste and Chlorhexidine gel, in the management of pain, facial swelling, and trismus resulting from lower third molar surgical extraction. Aim of the study: The study was meant to compare the effects of 0.2% chlorhexidine gel and Alvogyl paste on the reduction of the inflammatory reaction caused by the surgical extraction of the impacted mandibular third molar, which includes pain, facial swelling, and trismus.


Clinical Trial Description

Background: One of the most frequent surgical operations in dentistry is the surgical extraction of the impacted mandibular third molar, which is accompanied by a sequelae of swelling, trismus, and pain. Various techniques have been employed to either prevent or reduce these postoperative outcomes. Aim of the study: The study was meant to compare the effects of 0.2% chlorhexidine gel and Alvogyl paste on the reduction of the inflammatory reaction caused by the surgical extraction of the impacted mandibular third molar, which includes pain, facial swelling, and trismus. Materials and Methods: This randomized control study was conducted from February 2022 to September 2022 on (51) patients, (23) male and (28) female, aged (18-39) years, who presented with impacted mandibular third molar. The participants were randomly allocated into three groups, 17 patients received Alvogyl paste (G1), 17 patients received 0.2% Chlorhexidine gel (Periokin) (G2), and 17 patients received nothing upon surgery (G3). The mouth opening and facial measurements were assessed preoperatively as a baseline reference and on the 2nd and 7th postoperative days. pain was assessed daily using a numerical rating scale (NRS) from the first day to the seventh day following surgery. Results: Regarding the mouth opening, there was no statistically significant difference among the three groups in the degree of trismus on the second and seventh postoperative days (P ≥ 0.05). In regards to postoperative facial edema and pain, there was a statistically significant difference among all groups (P < 0.05), however, there was no statistically significant difference between the two study groups. Conclusion: This study showed that Alvogyl paste and 0.2% Chlorhexidine bioadhesive gel significantly reduce postoperative pain and facial swelling with no significant effect on trismus following impacted mandibular third molar surgical extraction. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06144983
Study type Interventional
Source University of Baghdad
Contact
Status Completed
Phase Phase 4
Start date February 1, 2022
Completion date September 1, 2022

See also
  Status Clinical Trial Phase
Completed NCT06023524 - The Effectiveness of Laser Acupuncture and Standard Medication Therapy on Mandibular Post-Odontectomy Patients N/A
Completed NCT02547896 - Effectiveness of Diclofenac and Its Association to Codeine After Lower Third Molar Extraction. Phase 4
Completed NCT05684601 - Impact of 3D Intraoral Scanning on Postsurgical Evaluation of Mandibular Third Molar Surgery N/A
Completed NCT05170516 - The Effect of Saline Irrigation at Different Temperatures on Pain, Edema, and Trismus After Impacted Third Molar Surgery N/A
Completed NCT02481700 - Epidemiological Study on the Surgical Removal of Third Molars
Completed NCT05488028 - 3D Evaluation of Facial Swelling Post Impacted Lower Third Molars Surgery: RCT N/A
Completed NCT05679973 - Evaluation of the Efficacy of Polybutester Suture on Postoperative Complications in Lower Impacted Third Molar Surgery N/A
Recruiting NCT03741894 - Examination of the Prevention and Treatment Modalities of Alveolitis in Relation With Impacted Teeth Surgery Phase 4
Completed NCT06017570 - Risk Factors for Distal Caries of Second Molars Adjacent to Mandibular Impacted Third Molars N/A
Completed NCT03894722 - Effects of Polyvinylpyrrolidone Iodine on Postoperative Trismus and Swelling During Impacted Third Molar Surgery Phase 4
Completed NCT02837614 - Evaluation of Preoperative Submucosal Dexamethasone in Third Molar Surgery Phase 0
Completed NCT02831374 - Effectiveness of Platelet Rich Plasma in Wound Healing Phase 0
Completed NCT02494856 - Comparison of the Clinical Efficacy of Naproxen, Associated or Not With Esomeprazol, in Lower Third Molar Removal Phase 4
Completed NCT02450487 - Influence of Genotype of CYP2C9 on Clinical Efficacy and Pharmacokinetics of Piroxicam After Lower Third Molar Surgery Phase 4
Completed NCT05545553 - Piezosurgery and Conventional Rotary Instruments on Third Molar Surgery N/A
Recruiting NCT03619460 - Clinical Efficacy of a New Piezoelectric Technique for Wisdom Teeth Extraction N/A
Not yet recruiting NCT05143359 - Accuracy of Variables for Impacted Mandibular Third Molar Surgery N/A
Completed NCT03784638 - Comparison of Two Different Flap Designs for Bilateral Impacted Mandibular Third Molar Surgery N/A
Completed NCT03752255 - Verbal and Visual Information Techniques on Anxiety in Third Molar Surgery N/A
Active, not recruiting NCT04349579 - Evaluation of the Effects of Irrigation of the Extraction Socket With Rifamycine Phase 4