Immunotherapy Clinical Trial
Official title:
Monitoring Allergen Immunotherapy in Allergic Rhinitis; is Nasal Fluid the Way to Precision Medicine?
Allergic rhinitis (hay fever) can be treated successfully with allergen-specific immunotherapy (AIT) for 3-5 years. This relative expensive and prolonged treatment is not suitable for everyone and therefore it is important to predict who will benefit from this therapy early after the start of treatment. This project will investigate whether a BAT with nasal fluid can detect inhibition during immunotherapy in comparison with a BAT with blood.
Status | Recruiting |
Enrollment | 25 |
Est. completion date | March 31, 2023 |
Est. primary completion date | December 23, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - IgE-sensitized birch pollen allergy - Start of Itulazax therapy or immunosuppressive therapy (nasal corticosteroid and/or antihistamine eye drops) - Signed informed consent Exclusion Criteria: - Other underlying chronic conditions (immunological (autoimmune or immunodeficiency), oncological) - Unstable uncontrolled asthma - Smoking |
Country | Name | City | State |
---|---|---|---|
Netherlands | Rijnstate Hospital | Arnhem |
Lead Sponsor | Collaborator |
---|---|
Rijnstate Hospital | Wageningen University |
Netherlands,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | BAT outcome nasal fluid | 8 weeks | ||
Primary | BAT outcome nasal fluid | 16 weeks | ||
Primary | BAT outcome serum | 8 weeks | ||
Primary | BAT outcome serum | 16 weeks | ||
Secondary | IgG4/IgA-associated inhibitory activity in nasal fluid | 8 weeks | ||
Secondary | IgG4/IgA-associated inhibitory activity in nasal fluid | 16 weeks | ||
Secondary | IgG4/IgA-associated inhibitory activity in serum | 8 weeks | ||
Secondary | IgG4/IgA-associated inhibitory activity in serum | 16 weeks |
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