Clinical Trials Logo
  1. Home
  2. Immunity
  3. NCT00468962
  4. Details
NCT00468962 Clinical Trial

The Effct of Chitooligosaccharide on Immune Function in Healthy Adults

Immunity Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00468962
Other study ID # 07-05
Secondary ID
Status Completed
Phase Phase 4
First received May 2, 2007
Last updated May 2, 2007

Study information
Verified date May 2007
Source Eulji University Hospital
Contact n/a
Is FDA regulated No
Health authority Korea: Food and Drug Administration
Study type Interventional

Clinical Trial Summary

Functional properties of chitooligosaccharides have been studied for antitumor activity, immunostimulating effects, antimicrobial activity, free radical scavening activity, adn angiotensin I converting enzyme inhibitory activity. Recent in vitro, and in vivo toxicity and absorbability studies have demonstrated that chitooligosaccharides have high absorbability and are essentially non-toxic. In the present study, we prepared a chitooligosaccharide with high absorbability and evaluated its effects on activation of immune function and cardiovascular funciton(lipid, atrial stiffness, etc) in healthy adults.

This study was a 8-week, randomized, double-blind clinical trial. The 30 volunteers were divided into a control group(n=10), half dose chitooligosaccaride(FACOSTM) intake group(n=10), and full dose FACOS intake group(n=10). Peripheral blood mononuclear cells(PBMCs) were isolated and cultured in 12 well plate for 48 hours. Cytokine production by PBMCs pre- and postintervention were measured simultaneously after stimulation with lipopolysaccaride.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers
Gender Both
Age group 20 Years to 50 Years
Eligibility Inclusion Criteria:

- healthy adults(the ages between 20~50 year)

Exclusion Criteria:

- food allergy and allergy skin disease

- severe liver and kidney disease

- pregnant, lactating women

- cancer, stroke, etc.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind

Related Conditions & MeSH terms

Intervention

Drug:
• FACOS (functional food)

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Eulji University Hospital
See also
  Status Clinical Trial Phase
Completed NCT02814617 - The Efficacy and Safety of Cordyceps Sinensis Mycelium Culture Extract(Paecilomyces Hepiali, CBG-CS-2) on Promotion of Immunity Phase 2/Phase 3
Completed NCT02244372 - Efficacy and Safety of Cordyceps Sinensis Mycelium Culture Extract(Paecilomyces Hepiali, CBG-CS-2) on Promotion of Immunity N/A
Completed NCT00990002 - Investigation of A Children's Beverage Containing Different Probiotics N/A
Completed NCT00788021 - Protective Immunity Project 01 N/A
Completed NCT01736787 - Efficacy and Safety of Cauliflower Mushroom Extract on Promotion of Immunity N/A
Recruiting NCT04579588 - Understanding Immunity to the Flu Vaccine in COVID-19 Patients
Completed NCT04798677 - Efficacy and Tolerability of ABBC1 in Volunteers Receiving the Influenza or Covid-19 Vaccine N/A
Completed NCT05162820 - Impact of Solarplast® on Immunity in Active Smokers and Non-smokers N/A
Completed NCT01657656 - Vitamin D Supplementations as Adjunct to Anti-Tuberculosis Drugs in Mongolia N/A
Completed NCT05585021 - Clinical Study on the Effect of Probiotic Compound Powder on the Immunity Improvement of Preschool Children N/A
Recruiting NCT05117385 - The Effect of the Consumption of 4 Botanical Extracts on Immunity in Healthy Adults (B-4-Immune) N/A
Completed NCT05190237 - the Efficacy and Safety of Fermented Soybean(Doenjang Powder) on Intestinal Microflora and Immune Enhancement. N/A
Completed NCT04647071 - Allium Extracts on the Incidence of Respiratory Infection Symptoms in Healthy Elderly Volunteers N/A
Completed NCT04031222 - Mechanisms of Inflammation, Immunity, Islet Cell and Intestinal Hormone Changes in Youth at Risk for Diabetes
Completed NCT04010331 - Efficacy and Safety of Nokyong Mixture Extract(CME-PI) on Promotion of Immunity N/A
Completed NCT03067714 - A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on Gut Microbiota Composition and Clinical Effectiveness in Infants at High Risk of Developing Allergy Phase 3
Completed NCT04664309 - Understanding Immunity to the COVID-19 Vaccines
Withdrawn NCT06121362 - Effect of Protocatechuic Acid on Biochemical Markers of Immunity Status in Healthy Adults N/A
Recruiting NCT02166931 - BRAND'S® Essence of Chicken in the Promotion of Resilience and Resistance to Stress-associated Cognitive Inhibition N/A
Recruiting NCT00645996 - The Influence of Probiotics on the Immunologic Response to Vaccinations in Infants N/A