Clinical Trials Logo
  1. Home
  2. Immune Tolerance
  3. NCT01414504

Pneumococcal Conjugate Vaccine Followup — PCVFU  

Immune Tolerance Clinical Trial

Official title:
Pneumococcal Conjugate Vaccine Followup: Investigation of Serotype-specific Antibody Persistence and B Cell Memory at Age 3-5 Years Following 23valent Pneumococcal Polysaccharide Vaccine at Age 9 Months in PNG Children Previously Primed With 7valent Pneumococcal Conjugate Vaccine

Clinical Trial Summary

Recently, controversy has emerged regarding the role of the 23vPPV in infants due to potential immunological hypo-responsiveness (i.e. a poorer immune response to repeat vaccination). Although previous experience of 23vPPV in children in PNG has demonstrated protective efficacy against acute lower respiratory tract infection, the investigators feel it is a matter of urgency to determine if 23vPPV administration provides elevated antibody concentrations at 3 to 5 years of age, and to ensure the immunological safety of the 23vPPV in infants.

Following consent and eligibility assessment, a baseline blood sample and nose swab will be taken, a 0.1ml dose of 23vPPV will be administered and a follow up blood sample and nose swab will be collected 28 days later. The investigators will also collect data on incidence of ALRI in all study participants by medical record review.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01414504
Study type Interventional
Source Papua New Guinea Institute of Medical Research
Contact
Status Completed
Phase Phase 2
Start date December 2009
Completion date September 2012
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT04621916 - Preventing Inhibitor Recurrence Indefinitely Phase 4
Recruiting NCT06243289 - Improving KIdney Transplantation With Cellular Therapy Study
Recruiting NCT03591302 - Delayed Blood Stem Transplantation in HLA Matched Kidney Transplant Recipients to Eliminate Immunosuppressive Drugs. Phase 1
Completed NCT04525456 - Immune Responses With Reduxium N/A
Recruiting NCT04314518 - The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications
Enrolling by invitation NCT04571203 - Kidney and Hematopoietic Cell Transplants Using a Regimen to Promote Hematopoietic Cell Engraftment Phase 1
Recruiting NCT01367821 - Immune Function in Patients With Obstructive Jaundice N/A
Enrolling by invitation NCT01117077 - The Immune Tolerance Mechanism Induced by IL-17-producing Regulatory T Cells in the Orthotopic Liver Transplant Recipients With Aspergillosis N/A
Recruiting NCT05010174 - Long-term Safety Follow-up in Recipients Who Previously Received Medeor's Cellular Immunotherapy Products
Active, not recruiting NCT03744325 - Immune Responses in Hen's Egg Oral Immunotherapy N/A
Completed NCT03383211 - Immune Response to BCG Vaccination in Neonates Born to HIV and LTBI Infected and Non-infected Mothers
Recruiting NCT02861872 - Intra-peritoneal Chemotherapy in Ovarian Cancer N/A
Active, not recruiting NCT00319657 - Kidney and Blood Stem Cell Transplantation That Eliminates Requirement for Immunosuppressive Drugs Phase 1/Phase 2
Completed NCT01538485 - Vitamin D Supplementation and Regulatory FoxP3+ T Cells in the GUT Phase 4
Completed NCT03393793 - HEart trAnsplantation Registry of piTie-Salpetriere University Hospital
Completed NCT01996774 - Immunologic Profile of Children With Severe Allergies to Peanuts and Nuts After Induction of Tolerance N/A
Recruiting NCT03292445 - Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation Early Phase 1
Active, not recruiting NCT05745792 - Clinico-immunological Characterization and Immune Tolerance Breakdown in HU-autoimmunity
Completed NCT02642237 - The Effects of Preceding LPS Administration on the Fluenz-induced Immune Response N/A
Not yet recruiting NCT06147375 - Efficacy and Safety of Immunosuppressive Withdrawal After Pediatric Liver Transplantation N/A