Immune Thrombocytopenia Clinical Trial
Official title:
Evaluation of Oxidant Status in Patients With Immune Thrombocytopenia (ITP) and the Role of an Adjuvant Antioxidant Therapy
Oxidative stress occurs as a result of increased activity of free radical-producing enzymes, decreased activity of free radical-removing enzymes, and insufficient levels of antioxidants. The most sensitive molecules to oxidation are lipids. Loss of cell membrane elasticity, increased cell fragility, and a shortened cellular life span results from oxidation of cell membrane lipids.
Free oxygen radicals may have an effect on the structural and functional damage of platelets
and plays a role in pathogenesis of thrombocytopenia in both, acute and chronic ITP.
Selenium is an essential mineral found in small amounts in the body. It works as an
antioxidant, especially when combined with other antioxidants as vitamin E , A and C.
Antioxidants neutralize free radicals and may reduce or even help prevent some of the damage
they cause.
aim of this study is to assess oxidant and antioxidant systems initially in patients with
acute and chronic immune thrombocytopenia (ITP) and 6 months later.Another aim of the study
is to evaluate effect of antioxidant therapy on bleeding score, platelet count and
antioxidant status during 6 months follow-up.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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