Immunologic Effect of Fraction of Inspired Oxygen

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

During anesthesia and surgery, oxygen is routinely administered to all patients. Inspired oxygen concentrations, however, vary between 30% - 100% and oxygen is often administered in a seemingly random manner.A striking conundrum is evident immediately when one review studies on the effects of oxygen on cytokines synthesis. Most investigators have found that hyperoxia enhances proinflammtory cytokines transcription and translations (11). In contrast, hyperparic oxygen has generally been shown to suppress stimulus induced porinflammtory cytokine production (12). Other studies have demonstrated that supplemental oxygen improves inflammatory and immune function (13), and it is not associated with clinically important side effect (14). We therefor undertook the current prospective randomized study to investigate whether perioperative supplemental oxygen (30% versus 80%) on pro and anti-inflammatory response in patients undergoing major abdominal cancer surgeries as our primary outcome. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04772794
Study type	Interventional
Source	Assiut University
Contact	Shereen M Kamal, Associate Professor
Phone	01006279209
Email	sheridouh79@yahoo.com
Status	Recruiting
Phase	N/A
Start date	January 13, 2020
Completion date	May 2022

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