Immunologic Effect of Fraction of Inspired Oxygen

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

During anesthesia and surgery, oxygen is routinely administered to all patients. Inspired oxygen concentrations, however, vary between 30% - 100% and oxygen is often administered in a seemingly random manner.A striking conundrum is evident immediately when one review studies on the effects of oxygen on cytokines synthesis. Most investigators have found that hyperoxia enhances proinflammtory cytokines transcription and translations (11). In contrast, hyperparic oxygen has generally been shown to suppress stimulus induced porinflammtory cytokine production (12). Other studies have demonstrated that supplemental oxygen improves inflammatory and immune function (13), and it is not associated with clinically important side effect (14). We therefor undertook the current prospective randomized study to investigate whether perioperative supplemental oxygen (30% versus 80%) on pro and anti-inflammatory response in patients undergoing major abdominal cancer surgeries as our primary outcome. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04772794
Study type	Interventional
Source	Assiut University
Contact	Shereen M Kamal, Associate Professor
Phone	01006279209
Email	sheridouh79@yahoo.com
Status	Recruiting
Phase	N/A
Start date	January 13, 2020
Completion date	May 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02277080` - The Immune and Endocrine Systems in Chronic Non-cancer Patients Treated With Opioids
Active, not recruiting	`NCT05026242` - Effects of Almond Consumption on Innate and Adaptive Immune System	N/A
Completed	`NCT04701502` - Efficacy and Safety of Viusid and Asbrip in Hospitalized Patients With Mild and Moderate COVID-19	Phase 2
Terminated	`NCT05133128` - An Experimental Medicine Clinical Study to Compare Peripheral Immune System From Subjects Without Cancer Diagnosis and Patients With Solid Tumours.	N/A
Recruiting	`NCT05792137` - Postprandial Monocyte Study	N/A
Completed	`NCT05329337` - Link Between the Peripheral Mononuclear Cells' Capacity to Induce Insulin Resistance and Hyperinsulinemia	N/A
Completed	`NCT06263686` - Evaluation of the Effects of Routine Intake of Fresh vs- Pasteurized Yoghurt on the Immune System in Healthy Adults	N/A
Recruiting	`NCT06312423` - Safety and Pharmacokinetics of IMT504, an Immunomodulator and Tissue Repair Inducer	Phase 1
Completed	`NCT00753402` - The Effects of Epinephrine in Endotoxemia in Normal Volunteers	Phase 1
Completed	`NCT00820989` - Inflammation and the Host Response to Injury (In Healthy Volunteers)	Phase 1
Completed	`NCT05221996` - Minimal-Dose Resistance Training for Improving sIgA and Cortisol	N/A
Completed	`NCT04275440` - Effects of Caloric Restriction and Exercise on Body Weight, Immune Function, and Intestinal Flora	N/A
Recruiting	`NCT06109337` - Immunoprofilling of Peripheral Blood Mononuclear Cells in Children With Attention Deficit/Hyperactivity Disorder
Recruiting	`NCT05648136` - Immune Profile Analysis and Biomarker Identification in Women With Repeated Implantation Failure or Unexplained Recurrent Spontaneous Miscarriage	N/A
Completed	`NCT06190379` - Aromatherapy for Upper Respiratory Health	N/A
Recruiting	`NCT05334888` - Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach
Completed	`NCT00730626` - Dose Response Study of a Fermented Yogurt on the Immune System and Gut Health	N/A
Recruiting	`NCT06400212` - CytoHealth - A Study of the Inflammatory Response to Exercise	N/A