Immune System Diseases Clinical Trial
Official title:
Immune and Genetic Correlates of Response to Zoster Vaccine in the Frail Elderly: a Pilot Study
This study is being done to evaluate the zoster vaccine response in the nursing home elderly (80 years or older). As the immune system ages, the response to vaccines is not always as strong as in younger people. Previous zoster vaccine studies have excluded nursing home residents so the vaccine effect in this population is not known. Furthermore, the immune and genetic reasons as to why the vaccine works well in some people but not in others are also unknown. The goal of this study is to evaluate why some immune systems respond well to the vaccine and why others do not.
Deleterious changes in immunity that occur with aging are known as immunosenescence. Such
changes, particularly in adaptive immunity, may lead to an impaired vaccine response in the
elderly. Characterizing the immune determinants and the genetic basis for vaccine response in
the frail elderly is a practical approach to better our understanding of immunosenescence.
Data on genetic determinants to immunization are sparse, furthermore, to the best of our
knowledge, none exist in the elderly. In this pilot study, we propose studying the immune
response to the herpes zoster vaccine and the underlying genetic determinants of the immune
response in elderly residents of nursing homes.
The three specific aims of this study are to generate data in order to 1) assess the T-cell
response to the varicella-zoster virus (VZV) vaccine in the frail elderly; 2) assess whether
immune (T-cell) phenotypes are associated with a response; 3) test the association between
immune response genotype sets and T-cell response. We hypothesize that response to the VZV
vaccine in elderly nonambulatory nursing home residents is a function of characteristic
T-cell immune phenotypes prior to vaccination and that there are immune genetic polymorphisms
associated with the response. This study will allow us to generate preliminary data and
establish feasibility in order to address these questions fully in a larger population in a
subsequent grant application.
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