Immune Responses Induced by Different Licensed Influenza Vaccines

Status Completed

Clinical Trial Summary

The goal of this research is to find out how the body's immune system responds to different manufacturer's "flu" vaccines.

Clinical Trial Description

There are currently five licensed inactivated influenza vaccines approved for use in the United States by the Food and Drug Administration.Current influenza virus vaccines consist of 3 components: the HA protein from an H1N1 virus, an H3N2 and an influenza B virus.Influenza vaccines are evaluated and approved by the FDA on the basis of HA and NA content. However, different manufacturing processes are involved in the preparation of these commercial vaccines and evidence suggests that each of these vaccines contain similar patterns of HA protein but different patterns of influenza influenza internal proteins such as NP and M1. The presence of these additional internal proteins of influenza virus which are targets of T cell responses suggest not only the potential for additional protection derived from influenza vaccines other than antibody mediated protection but also differential levels of T cell mediated protection between different manufacturers of commercial influenza vaccines.Each subject will have four blood samples taken- prevaccination and at Days 7, 14,30 and 3-5 months post vaccination. These samples will be tested for T and B cell responses and the results compared between different manufacturers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00902278
Study type	Interventional
Source	University of Massachusetts, Worcester
Contact
Status	Completed
Phase	N/A
Start date	October 2008
Completion date	April 2016

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