Immune Response Clinical Trial
— ImFITOfficial title:
Physical Activity, Aging and Immune Function
Verified date | January 2009 |
Source | National Institute on Aging (NIA) |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Interventional |
The purpose of the study is to examine whether cardiovascular exercise training improves immune responses to vaccination in previously sedentary older adults.
Status | Completed |
Enrollment | 150 |
Est. completion date | July 2006 |
Est. primary completion date | July 2006 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 62 Years to 82 Years |
Eligibility |
Inclusion Criteria: - Ages 62-82 - Ability to participate in an exercise program - Medical clearance by primary physician - Non-smoker - BMI 22-38 - Independently living - Post-menopausal - Sedentary for over 6 months Exclusion Criteria: - No recent history (within 6 months) of infection or vaccination - History of systemic reactions to vaccination - History of cancer - Severe allergies/asthma requiring prescription medication - Splenectomy or transplant patient - Chronic Obstructive Pulmonary Disease (COPD) - HIV positive - Uncontrolled diabetes or hypertension - Severe arthritis - Mental illness or clinical depression - Impaired cognitive status |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | University of Illinois at Urbana-Champaign | Urbana | Illinois |
Lead Sponsor | Collaborator |
---|---|
National Institute on Aging (NIA) |
United States,
Kohut ML, Cooper MM, Nickolaus MS, Russell DR, Cunnick JE. Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals. J Gerontol A Biol Sci Med Sci. 2002 Sep;57(9):M557-62. — View Citation
Woods JA, Ceddia MA, Wolters BW, Evans JK, Lu Q, McAuley E. Effects of 6 months of moderate aerobic exercise training on immune function in the elderly. Mech Ageing Dev. 1999 Jun 1;109(1):1-19. — View Citation
Woods JA, Lowder TW, Keylock KT. Can exercise training improve immune function in the aged? Ann N Y Acad Sci. 2002 Apr;959:117-27. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | antibody responses to influenza and tetanus toxoid vaccination and delayed type hypersensitivity responses to fungal antigens | baseline, 6 and 10 months | ||
Secondary | cardiovascular fitness | |||
Secondary | psychosocial outcomes |
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