Immobilization Clinical Trial
— ESDIMOfficial title:
The Effects of Daily Neuromuscular Electrical Stimulation on Muscle Mass During Short-term One-legged Knee Immobilization in Healthy Young Men
In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.
Status | Completed |
Enrollment | 24 |
Est. completion date | January 2013 |
Est. primary completion date | December 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Male - Aged from 18-35 years - 18.5 < BMI < 30 kg/m2 Exclusion Criteria: - Smoking - Performing regular resistance training in the previous 6 months - Hypertension (according to WHO criteria) [46] and/or cardiovascular disease - Any back/leg/knee/shoulder complaints which may interfere with the use of crutches - Use of any prescribed medication - Type 2 diabetes mellitus - Any family history of thrombosis - All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis). - Myocardial infarction within the last 3 years - Use of anti-coagulants |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
Netherlands | Maastricht University Medical Centre | Maastricht |
Lead Sponsor | Collaborator |
---|---|
Maastricht University Medical Center |
Netherlands,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | muscle mass, muscle fiber size | three days before immobilization, and directly after immobilization (day of cast removal; day 6) | No | |
Secondary | muscle strength measured by quadriceps 1-Repetition Maximum by Leg Extension | three days before immobilization, and directly after immobilization (day of cast removal; day 6) | No |
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