Immediate Implant Placement Clinical Trial
Official title:
Immediately Placed Implants Using Simvastatin and Autogenous Tooth Graft Combination in Periodontally Compromised Sites: A Randomized Controlled Clinical Trial
Recently, autogenous tooth graft (ATG) made from compromised teeth was applied in bone defects and resulted in a good clinical efficacy.(6) Moreover, it is more accepted by patients to use extracted teeth as a bone graft material, especially in the case of immediate implant placement. Simvastatin (SMV), known as a 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor, is widely used to decrease serum cholesterol because of its safe and effective treatment. Apart from cholesterol-lowering effects, SMV is also found to promote osteogenic differentiation of bone marrow stem cells (BMSCs), suppress osteoclastic differentiation in bone tissue and promotes osseointegration around implants in animal studies. SMV is reported to enhance autophagy and alleviates the ROS of BMSCs in the osseointegration of implants. The present study will be carried out to evaluate the effect of SMV combined with ATG on bone formation around immediately placed dental implants.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05670067 -
Alveolar Ridge and Soft Tissue Augmentation Using Graft From the Maxillary Tuberosity
|
N/A | |
Completed |
NCT05990283 -
Socket Shield Technique and Guided Bone Regeneration
|
N/A | |
Withdrawn |
NCT06038695 -
Immediate Implant Placement Using Volume-Stable Collagen Matrix Combined With rhPDGF-BB
|
N/A | |
Recruiting |
NCT05436158 -
The Use of a New Safe Angle Position for Implant Placement in the Anterior Region.
|
||
Not yet recruiting |
NCT06246253 -
Bone Formed Labial to the Implant in Relation to the Horizontal Gap Dimension in Immediate Implant Placement.
|
||
Not yet recruiting |
NCT06207565 -
Immediate Implant Placement Utilizing Vestibular Flap Versus Single Flap Approach With Bone Graft
|
N/A | |
Enrolling by invitation |
NCT05330702 -
Ultrasound-based Imaging to Detect Early Changes of Hard and Soft Tissue Around Immediately Placed Implants With or Without Soft Tissue Augmentation
|
N/A | |
Enrolling by invitation |
NCT05880771 -
Immediate Implant Placement: a Clinical and Radiographic Study on Hard and Soft Tissues Retraction at One Year.
|
N/A | |
Completed |
NCT04795102 -
Effect of "Autogenous Leukocyte Platelet Rich Fibrin- Tooth Graft" Combination Around Immediately Placed Implants
|
N/A | |
Completed |
NCT03422458 -
The Impact of Immediate Implant Placement on Alveolar Ridge Preservation Techniques
|
N/A | |
Completed |
NCT04803500 -
Simvastatin Around Immediate Implant
|
Phase 2 |