Clinical Trials Logo

Clinical Trial Summary

Recently, autogenous tooth graft (ATG) made from compromised teeth was applied in bone defects and resulted in a good clinical efficacy.(6) Moreover, it is more accepted by patients to use extracted teeth as a bone graft material, especially in the case of immediate implant placement. Simvastatin (SMV), known as a 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor, is widely used to decrease serum cholesterol because of its safe and effective treatment. Apart from cholesterol-lowering effects, SMV is also found to promote osteogenic differentiation of bone marrow stem cells (BMSCs), suppress osteoclastic differentiation in bone tissue and promotes osseointegration around implants in animal studies. SMV is reported to enhance autophagy and alleviates the ROS of BMSCs in the osseointegration of implants. The present study will be carried out to evaluate the effect of SMV combined with ATG on bone formation around immediately placed dental implants.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04992416
Study type Interventional
Source Kafrelsheikh University
Contact
Status Completed
Phase N/A
Start date September 2, 2021
Completion date December 15, 2022

See also
  Status Clinical Trial Phase
Active, not recruiting NCT05670067 - Alveolar Ridge and Soft Tissue Augmentation Using Graft From the Maxillary Tuberosity N/A
Completed NCT05990283 - Socket Shield Technique and Guided Bone Regeneration N/A
Withdrawn NCT06038695 - Immediate Implant Placement Using Volume-Stable Collagen Matrix Combined With rhPDGF-BB N/A
Recruiting NCT05436158 - The Use of a New Safe Angle Position for Implant Placement in the Anterior Region.
Not yet recruiting NCT06246253 - Bone Formed Labial to the Implant in Relation to the Horizontal Gap Dimension in Immediate Implant Placement.
Not yet recruiting NCT06207565 - Immediate Implant Placement Utilizing Vestibular Flap Versus Single Flap Approach With Bone Graft N/A
Enrolling by invitation NCT05330702 - Ultrasound-based Imaging to Detect Early Changes of Hard and Soft Tissue Around Immediately Placed Implants With or Without Soft Tissue Augmentation N/A
Enrolling by invitation NCT05880771 - Immediate Implant Placement: a Clinical and Radiographic Study on Hard and Soft Tissues Retraction at One Year. N/A
Completed NCT04795102 - Effect of "Autogenous Leukocyte Platelet Rich Fibrin- Tooth Graft" Combination Around Immediately Placed Implants N/A
Completed NCT03422458 - The Impact of Immediate Implant Placement on Alveolar Ridge Preservation Techniques N/A
Completed NCT04803500 - Simvastatin Around Immediate Implant Phase 2