Image Clinical Trial
— CTO-CMROfficial title:
Chronic Total Occlusive Lesions CMR Study
This registry will include consecutive patients presenting with at least one chronic total occlusion on coronary angiogram who will be treated by percutaneous coronary intervention in our center. All patients will undergo a non-invasive assessment for myocardial ischemia/viability using cardiac magnetic resonance (CMR) prior to revascularization therapy. Follow up CMR will be repeated in all participants after three months and one year. Additionally, clinical outcomes and quality of life will be evaluated at baseline and at follow-up. Primary objective of this study is to investigate the the reduction in ischemia (as evaluated by follow-up CMR) and the severity of angina according to clinical evaluation (including Seattle Angina Questionnaires [SAQ], Canadian Class Score[CCS] and 6-mins walking test).
Status | Recruiting |
Enrollment | 400 |
Est. completion date | December 1, 2025 |
Est. primary completion date | December 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Age > 18 years - Presence of at least one untreated CTO at basal angiography (defined as a total occlusion in any major coronary vessel or relevant side branches [reference vessel diameter =2.5mm or as judged by two independent interventional cardiologists], with TIMI 0 in the distal segment and at least 3 months old - Patient has a clinical indication to perform CTO PCI - Willing to participate and able to understand, read and sign the informed consent document. Exclusion Criteria: - CMR contraindications - Contraindications to adenosine or dobutamine - Severe chronic kidney disease (estimated Glomerular Filtration Rate [eGFR] <60 mL/min/1.73m2 or serum creatinine level >2.5 mg/dL) |
Country | Name | City | State |
---|---|---|---|
China | Beijing anzhen hospital | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Lin Zhao |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in ischemia | Parameters of cardiac magnetic resonance | 3 months; 12 months | |
Secondary | Rate of target lesion failure (TLF). | TLF is defined as a composite of: cardiac death, target vessel myocardial infarction (SCAI definition), and clinically driven TLR. | 12 months | |
Secondary | Changes in angina paramteres | Parameters of angina questionnaires. | 3 months; 12 months | |
Secondary | Change of left ventricular structure and function | Parameters of left ventricular function and structure on cardiac magnetic resonance | 3 months; 12 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06035250 -
AI Prediction of Gastric Cancer Response to Neoadjuvant Chemotherapy
|
||
Not yet recruiting |
NCT05539261 -
Research on Neurological Prognosis of Patients Undergoing Heart Valve Surgery
|
||
Recruiting |
NCT05043662 -
UroCAD Assay Combined With Computed Tomography Urography and Urine Cytology for UTUC Diagnosis.
|
||
Recruiting |
NCT05446155 -
BioMEL- Diagnostic and Prognostic Factors in Melanoma.
|
||
Recruiting |
NCT06182683 -
Concurrent OCT and FFR-guided PCI in CAD
|
N/A | |
Not yet recruiting |
NCT06097741 -
Pulmonary MRI Using Ultra Short /Zero TE Sequences
|
N/A | |
Recruiting |
NCT05776602 -
Fast Brain MRI in Children With Suspected Brain Tumor
|
||
Not yet recruiting |
NCT05848921 -
Evaluation of Brain Health and Surgical Efficacy in Patients With Carotid Artery Stenosis
|
||
Not yet recruiting |
NCT05848934 -
Research on the Relationship Between Cognitive Function Changes and Cerebrovascular Health in Patients With Coronary Heart Disease
|
||
Active, not recruiting |
NCT04689529 -
Unnecessary Mastectomy Due to False Size Prediction by Preoperative Imaging Studies in Breast Cancer
|
N/A | |
Recruiting |
NCT05820165 -
Brain Imaging in Cerebral Venous Outflow Disturbance
|
||
Completed |
NCT05674097 -
Blood Flow Path Reconstruction in Rectal Cancer
|
||
Not yet recruiting |
NCT05697406 -
HP Pyruvate MRI in Cancers
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT06017193 -
Ultrasound for Socket Healing Evaluation
|
||
Not yet recruiting |
NCT06127810 -
MRI Gadopiclenol Enhanced Imaging of CNS Tumors
|
||
Completed |
NCT04498611 -
Prediction of Upgrade to Invasive Cancer in Patients Diagnosed With Ductal Carcinoma in Situ by Percutaneous Core Needle Biopsy
|
N/A | |
Completed |
NCT05538793 -
Deep Learning for the Discrimination Among Different Types of Keratits: a Nationwide Study
|
||
Recruiting |
NCT06280690 -
SGM-101 Tumor Targeted Fluorescence Endoscopy in Rectal Polyps With Suspected T1 Adenocarcinoma or High Grade Dysplasia
|
Phase 2 | |
Completed |
NCT06056531 -
Peripheral Intravenous Cannulation Using Three Different Techniques on Nursing Students
|
N/A | |
Completed |
NCT05004597 -
3D Craniofacial Morphologic Development of Healthy Infants
|
N/A |