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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05622565
Other study ID # 2021KYPJ164
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 2011
Est. completion date July 2024

Study information

Verified date July 2023
Source Sun Yat-sen University
Contact Yingfeng Zheng, M.D. Ph.D
Phone +8613922286455
Email zhyfeng@mail.sysu.edu.cn
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To establish a deep learning system of various ocular fundus disease analytics based on the results of multimodal examination images. The system can analyze multimodal ocular fundus images, make diagnoses and generate corresponding reports.


Description:

The ocular fundus is the only part of the human body that can directly see the blood vessel microcirculation and nerve tissue. Through various imaging tests, including Color Fundus Photograph (CFP), Optical Coherence Tomography (OCT), Fluorescein Fundus Angiography (FFA) and Indocyanine Green Angiography (ICGA), etc., it is possible to statically overview or dynamically observe the retina and choroid, the condition of blood vessels and nerves, and comprehensive diagnosis of the disease. The screening, interpreting and accurate diagnosis of ocular fundus diseases are crucial for disease prevention, control and precise treatment. However, due to the variety of fundus examination methods, and the complexity and professionalism of the examination, there is a lack of fundus specialists who have sufficient clinical experience and knowledge to interpret fundus examinations. With the continuous development of artificial intelligence (AI) in diagnosing fundus diseases, various modalities of imaging examination methods are gradually applied to the development of fundus disease diagnosis systems. Moreover, medical images often come with corresponding reports, which are mostly generated by clinicians' or radiologists' experience. Here, we are establishing a fundus disease diagnosis and report-generating system based on cross-modal ocular fundus imaging examinations, and fundus lesions were visualized at the same time. Multi-center data verification will also be conducted. The results of the research will assist in fundus lesions diagnosis and imaging reports generation. We hope this could popularize more complex fundus imaging examination methods to society, and help improve the early diagnosis and treatment of fundus lesions that cause blindness.


Recruitment information / eligibility

Status Recruiting
Enrollment 15000
Est. completion date July 2024
Est. primary completion date December 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - The quality of multimodal ocular fundus disease examination images and corresponding reports should be clinically acceptable. Exclusion Criteria: - Reports with key information missing. - Images with severe image resolution reductions, blur or artifacts were excluded from further analysis.

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
Various modalities of ocular fundus imaging
Through various modalities of ocular fundus imaging, combining with clinical data and the experience of clinicians to diagnose different fundus diseases.

Locations

Country Name City State
China Zhognshan Ophthalmic Center, Sun Yat-sen University Guangzhou Guangdong

Sponsors (1)

Lead Sponsor Collaborator
Sun Yat-sen University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Area under the receiver operating characteristic curve of the deep learning system The investigators will calculate the area under the receiver operating characteristic curve of the deep learning system and compare this index with human ophthalmologists. Baseline
Secondary Intersection-Over-Union of the models' explanation accuracy The investigators will calculate the Intersection-Over-Union (IOU) (or Jaccard similarity) between the lesion-image attention mapping regions and ground truth regions of the deep learning system. Baseline
Secondary Sensitivity and Specificity of the deep learning system The investigators will calculate the sensitivity and specificity of the deep learning system. Baseline
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