Ideomotor Apraxia Clinical Trial
Official title:
Event-Related fMRI Analysis of Patients With Ideomotor Apraxia During Transitive and Intransitive Hand Gesturing
Ideomotor apraxia, a disorder that affects patients with stroke and a variety of other brain
lesions, features disturbed timing, sequence, and spatial organization of skilled movements.
This study will look at how different areas of the human brain control fine hand movements.
Thirty-five participants 21 years and older will be enrolled in this study-25 healthy,
right-handed people, and 10 stroke patients. They will undergo two outpatient sessions, each
lasting up to 3 hours. The first visit for the stroke patients will occur between 2 weeks and
3 months after the stroke; the second visit will be at least 6 months after the stroke.
Participants will have a physical exam, give a medical history, and complete a questionnaire.
Then they will undergo magnetic resonance imaging (MRI) scans. They will lie in the MRI
scanner and will be asked to do a number of skilled hand movements using the right hand (such
as pretending to use a hammer or waving goodbye) in response to directions that will appear
on a screen mounted over their head. Their movements will be recorded on videotape during the
procedures.
OBJECTIVE: The present study focuses on evaluating neural activation patterns underlying
praxis movements in normal controls and in patients with ideomotor apraxia using
event-related functional magnetic resonance imaging (fMRI). Ideomotor apraxia is a disorder
affecting patients with stroke and a variety of other brain lesions. The disorder involves
disturbed timing, sequence, and spatial organization of skilled movements, during the
execution and probably also preparatory phases. As a consequence, patients suffer from
incorrect temporal and spatial components to movements as evidenced during pantomime of
transitive (object/tool related) and intransitive (independent of object/tool use) gestures.
Thus far, damage to posterior parietal regions and parietofrontal circuits has been
implicated in significantly contributing to this disorder. However, little is known about the
mechanism of cortical reorganization following damage, notably during recovery process. We
hypothesize that recruitment of parallel and contralateral motor pathways compensates for
reduced communication within parietofrontal circuits which prevents accurate motor
performance.
STUDY POPULATION: We will study two groups of participants: one group of patients with
ideomotor apraxia and one group of healthy subjects.
DESIGN: We will measure fMRI activation on transitive and intransitive gestures in 10
patients with ideomotor apraxia during subacute and chronic stage compared to 25 normal
controls. The design of the behavioral paradigm incorporates a distinct period of planning
prior to each movement.
OUTCOME MEASURES: The design of this study allows evaluating any differences in the planning
and execution phases between patients and controls. Further analysis will examine patterns of
functional connectivity between activated brain areas, notably their altered interactions in
ideomotor apraxia. Of special interest is the putative engagement of perilesional or even
remote brain areas in a neuronal network during attempted recovery from motor deficit.
It is expected from the study that a better understanding of cortical plasticity compensating
for motor deficits in ideomotor apraxia can be therapeutically exploited, notably in the
rehabilitation process.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00024999 -
EEG and EMG Analysis of Ideomotor Apraxia
|
N/A | |
| Recruiting |
NCT03153371 -
Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks
|