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NCT05396066 Clinical Trial

Respiratory and Quadriceps Muscle Fatigability After an ICU Acquired Weakness

ICU Acquired Weakness Clinical Trial

Official title:
Comparison Between Respiratory and Quadriceps Muscle Fatigability During a Maximal Loading for ICU Weakness Patients

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05396066
Other study ID # 2021-A02816-35
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 15, 2022
Est. completion date January 1, 2023

Study information
Verified date August 2022
Source Groupe Hospitalier du Havre
Contact Clement Medrinal, PhD
Phone +33630039745
Email clement.medrinal@ch-havre.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Muscle dysfunction can be lead to poor outcomes moreover ICU muscle weakness recovery are not correctly described. The investigators aimed to assess the ability for quadriceps or respiratory muscles to repeat an effort at a maximal loading.

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date January 1, 2023
Est. primary completion date December 31, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Mechanically ventilated at least at 24 Hours - Maximal inspiratory pressure < 30 centimeter of water - MRC score < 48/60 Exclusion Criteria: - Age < 18 years - Patients with neurological pathology or pre existing neuromuscular dysfunction - Patient unable to walk 50 meters before ICU admission - Patient with a thoracic or abdominal surgery - Inability to carry out maximal voluntary contraction

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Muscle evaluation
Repeated maximal voluntary contraction

Locations
Country Name City State
France Groupe Hospitalier du Havre Montivilliers Groupe Hospitalier Du Havre

Sponsors (1)
Lead Sponsor Collaborator
Groupe Hospitalier du Havre

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Change in Respiratory muscle strength Respiratory muscle strength will be assessed by Maximal Inspiratory pressure in centimeter of water. The measure will carry out by an electronical manometer One day
Primary Change in quadriceps muscle strength Quadriceps muscle strength will be assessed by Maximal Voluntary contraction of the quadriceps in Newton. The measure will carry out by an electronical dynamometer One day
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