Risk Factors of ICU-acquired Weakness

ICU Acquired Weakness Clinical Trial

— ICU-AW  

Official title:

ICU-acquired Weakness in Extracorporeal Membrane Oxygenation Support: Frequency and Risk Factors

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04932330
• Other study ID #: 2021-0041
• Status: Recruiting
• Start date: March 1, 2017
• Est. completion date: June 1, 2022

Study information

• Verified date: June 2021
• Source: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Contact: xinyi chen, master
• Phone: 19858875700
• Email: chenxinyi0323[@]zju.edu.cn
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

We conducted a retrospective study of critical ill patients who used ECMO during their ICU stay. ICU-AW was diagnosed at the time when patients discharged and had a Medical Research Council (MRC) sum score < 48 out of a maximal score of 60. We divided patients to ICU-acquired weakness group and no ICU-acquired weakness group and compared their clinical characteristics. Baseline characteristics and therapy details were collected from the case report forms and inspection reports. Univariable analysis and logistic regression analysis were used to analyze clinical characteristics of individuals and to find risk factors of ICU-AW.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 85
• Est. completion date: June 1, 2022
• Est. primary completion date: March 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Critical ill patients who used extracorporeal membrane oxygenation during their ICU stay. Patients were recruited from the general ICU of the second affiliated hospital of Zhejiang University, between March 2017 to March 2020.

Exclusion Criteria:

• Patients who was less than 18 years old, had been proven or suspected neurological impairment, using extracorporeal membrane oxygenation less than 24 hours, severe head or spinal cord injury and pregnant woman.

Related Conditions & MeSH terms

• ICU Acquired Weakness

Locations

Country	Name	City	State
China	Xinyi Chen	Hangzhou	Please Select

Sponsors (1)

Lead Sponsor	Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Differences between ICU-acquired weakness in patients receiving extracorporeal membrane oxygenation support	We compared the clinical characteristics between ICU-acquired weakness group and no ICU-acquired weakness group by univariate analysis . Then we used logistic regression analysis and found out differences of ICU-acquired weakness.	1 day
Secondary	Frequency of ICU-acquired weakness in in patients receiving extracorporeal membrane oxygenation support	We calculated the prevalence of ICU-acquired weakness on the patients included in our research.	1 day