ICSI Clinical Trial
Official title:
Luteal Phase Support With Estradiol In Poor Responders Undergoing In Vitro Fertilization
The role of progesterone (P) supplementation in the luteal phase of in vitro fertilization (IVF) cycles is well established world-wide , but the influence of the luteal phase estradiol level on implantation is not clearly defined . There is a significant difference in estradiol levels between fertile and infertile cycles of fertile women who underwent donor insemination.
Status | Recruiting |
Enrollment | 170 |
Est. completion date | September 1, 2019 |
Est. primary completion date | August 1, 2019 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 35 Years to 44 Years |
Eligibility |
Inclusion Criteria: - Participants included in this study will have the following criteria : ( 2 of 3 criteria ) 1. advanced maternal age or any other risk factor for POR : 1. Age =35 years 2. other risk factor of poor responder : ovarian surgery especially in case of endometrioma , chemotherapy, radiotherapy, autoimmune disorders, single ovary, chronic smoking, and unexplained Infertility. 2. previous poor ovarian response : Number of oocytes at the pickup time 3 or less . 3. Abnormal ovarian reserve tests : 1. FSH =12 mIu/ml in the early follicular phase . 2. Estradiol level more than 70 pg/dl in the early follicular phase 3. Anti-Mullerian hormone (AMH) below 0.5-1.1 ng/ml. 4. Antral follicle count (AFC) < 5-7 follicles . Exclusion Criteria: 1. Age >35 with good ovarian response . 2. any intra-uterine pathology can affect receptivity , ( for example ; Sub-mucosal fibroid , intra-uterine adhesions ). 3. Severe male factor infertility. 4. Extended endometriosis (stage 3 or more) . 5. All contraindications for estradiol : venous thrombo-embolism , stroke and breast cancer |
Country | Name | City | State |
---|---|---|---|
Egypt | AinShams university maternity hospital | Cairo | Abbassya |
Lead Sponsor | Collaborator |
---|---|
Ain Shams University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | live birth rate | the number of deliveries that resulted in a live born neonate | at least 28 weeks after ET |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04795440 -
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
|
N/A | |
Not yet recruiting |
NCT05300841 -
The Effect of Pretreatment With Dydrogesterone Vs Combined Estradiol Valerate and Dydrogestrone on Clinical Pregnancy Outcome of ICSI in PCOS Patients"
|
Early Phase 1 | |
Recruiting |
NCT03913208 -
Priority to Cryopreservation Strategy (PCS) in IVF-ICSI Cycles
|
N/A | |
Active, not recruiting |
NCT02271490 -
Acrosome Reaction Induction Prior to ICSI
|
N/A | |
Recruiting |
NCT03398031 -
Effect of Magnesium Supplement in Early Pregnancy After ICSI
|
Phase 3 | |
Recruiting |
NCT02190006 -
Comparison Between the Role of Follicular Output Rate and Preovulatory Count in the Prediction of Pregnancy in Women With Polycystic Ovarian Syndrome Undergoing Intra Cytoplasmic Sperm Injection (ICSI)
|
N/A | |
Completed |
NCT04962074 -
Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods
|
N/A | |
Active, not recruiting |
NCT03470298 -
Retrieval Versus Mid-luteal Endometrial Scratching (ES) for Intra Cytoplasmic Sperm Injection (ICSI)
|
N/A | |
Completed |
NCT04547699 -
Cytokines Supplementation to Culture Media and ICSI Outcome
|
N/A | |
Completed |
NCT00561249 -
Randomized Prospective Trial on the Use of Laser Assisted Hatching (LAH) for Transfer of Frozen/Thawed Embryos in Human IVF/ICSI
|
N/A | |
Recruiting |
NCT04490889 -
Noninvasive Preimplantation Genetic Testing for Aneuploidy
|