Rebreathing-induced Hypoxia & Glucose Levels

Status Recruiting

Clinical Trial Summary

The aim of this research project is to determine the effect of repeated maximal voluntary apneas on glucose uptake during an oral glucose tolerance test in healthy individuals, individuals with prediabetes and patients with type 2 diabetes.

Clinical Trial Description

It is predicted that 1 in 3 adults will develop diabetes by 2050, implying that a large percentage of the population will become at high risk for cardiovascular disease, the most common cause of death in patients with type 2 diabetes. While regular exercise reduces insulin resistance and the elevated glucose levels associated with type 2 diabetes, only 28% of the adult population with diabetes meet physical activity recommendations. There is therefore an urgent need to identify alternative, non-pharmacological interventions that prevent and treat type 2 diabetes. A reduced oxygen availability, or hypoxia, is widely implicated in the development of insulin resistance. Paradoxically, hypoxia also triggers glucose uptake independently from the actions of insulin. Indeed, breathing low levels of oxygen stimulates glucose uptake in skeletal muscles by activating 5' adenosine monophosphate-activated protein kinase (AMPK). Discrepancies on the effect of hypoxia on glucose homeostasis may be attributed to the duration and type (nocturnal vs. diurnal) of hypoxic exposure. For example, the many severe hypoxic bouts associated with obstructive sleep apnea are associated with a worsened glycemic control while hypoxic exposure consisting of a limited number of short bouts of moderate hypoxia improves glycemic control. Therefore, an intervention that can induce brief hypoxic conditions, as observed through a reduced fraction of inspired oxygen, could attenuate the postprandial increase in glucose levels. Fraction of inspired oxygen can be reduced by rebreathing into a low-volume closed-circuit system containing ambient air for few minutes. Thus, the aim of this research project is to determine the effect of few bouts of rebreathing-induced hypoxia on glucose uptake during an oral glucose tolerance test in healthy individuals, individuals with prediabetes and patients with type 2 diabetes. If our expected outcomes are met, our next step will be to determine whether repeated sessions of rebreathing-induced hypoxia (5 sessions per week over 1-3 months) results in improvements in glycemic control. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05422430
Study type	Interventional
Source	University of Texas at Austin
Contact	Sophie Lalande
Phone	5122326485
Email	sophie.lalande@austin.utexas.edu
Status	Recruiting
Phase	N/A
Start date	October 21, 2021
Completion date	September 2025

View Details

See also
Status	Clinical Trial	Phase
Suspended	`NCT03628560` - Alternate Methodology of Pulse Oximeter Validation	N/A
Completed	`NCT02866578` - Open Lung Protective Ventilation in Cardiac Surgery	N/A
Recruiting	`NCT06139081` - Oxygen Delivery Methods of Nasal Catheter on the Incidence of Hypoxemia in Patients With Painless Gastroscopy	N/A
Not yet recruiting	`NCT05964309` - Pre-oxygenation in Sitting Position and Oxygen Reserve Index	N/A
Completed	`NCT00740220` - Reproducibility of 6 Minute Walk Tests for Oxygen Desaturation	N/A
Completed	`NCT00675415` - Does Capnography Prevent Hypoxemia During Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound?	N/A
Completed	`NCT04557605` - Effects of a Face Mask on Oxygenation During Exercise	N/A
Active, not recruiting	`NCT05479929` - Work of Breathing Assessment in Triage Scale
Recruiting	`NCT03009643` - Salvage Treatment of Inhaled Nitric Oxide in Patients With Refractory Hypoxemia After Aortic Surgery	N/A
Completed	`NCT01949012` - Capnography Monitoring During Intravenous Conscious Sedation Sedation With Midazolam for Oral Surgery	N/A
Completed	`NCT01477450` - Comparison of Oxygen Delivery Devices for Reversal of Altitude-Induced Hypoxemia in Normal Subjects	N/A
Completed	`NCT01470170` - Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy	Phase 4
Recruiting	`NCT06085859` - Anesthesia Endoscope Mask is Applied to Sedation Upper Gastrointestinal Endoscopic Diagnosis and Treatment	N/A
Recruiting	`NCT03969615` - SuperNO2VA™ and General Anesthesia Postoperative Care	N/A
Completed	`NCT02554110` - Peripheral Nerve Stimulation to Reduce Hypoxic Events	N/A
Completed	`NCT04566419` - poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence	N/A
Completed	`NCT04998253` - Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2	Early Phase 1
Recruiting	`NCT04079465` - Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia	N/A
Recruiting	`NCT06022523` - Accuracy of Pulse Oximeters With Profound Hypoxia	N/A
Completed	`NCT04159116` - Prevention and Treatment of Laryngospasm and Hypoxemia Based on Risk Factors in Adult Outpatients Undergoing EGD	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Rebreathing-induced Hypoxia and Glucose Levels

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms