Hypoxemia Clinical Trial
Official title:
Salvage Treatment of Inhaled Nitric Oxide in Patients With Refractory Hypoxemia After Aortic Surgery
Hypoxemia is a common complication after aortic surgery. As this complication has an adverse effect on the postoperative course of the patient, early treatment is important; however, the mechanism of hypoxemia after surgery for acute aortic dissection remains unclear. Recently, the investigators found that inhaled Nitric Oxide can improve the oxygenation in some of these patients. The investigators are trying to evaluate the effectiveness and safety of inhaled Nitric Oxide in patients with refractory hypoxemia after aortic surgery.
Several risk factors for severe hypoxemia after aortic surgery have been reported including
advanced age, obesity, smoking history, previous heart surgery,emergency surgery,reduced
cardiac function, advanced chronic obstructive pulmonary disease, excessive volume of blood
transfusion,and prolonged CPB time. The routine treatment includes lung protective mechanical
ventilation, recruitment maneuvers and glucocorticoids.
No previous clinical studies have reported the effectiveness and safety of inhaled Nitric
Oxide in patients with refractory hypoxemia after aortic surgery.
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