Clinical Trials Logo
  1. Home
  2. Hypoxemia
  3. NCT02866578

Open Lung Protective Ventilation in Cardiac Surgery — PROVECS  

Hypoxemia Clinical Trial

Official title:
Open Lung Protective Ventilation During Cardiac Surgery With Cardiopulmonary Bypass : a Randomized Controlled Trial

Clinical Trial Summary

Cardiac surgery with cardiopulmonary bypass (CPB) frequently induces post-operative respiratory dysfunction. The post-operative pulmonary complications (PPCs) significantly increase the peri-operative morbidity and require invasive treatments during longer and more expensive ICU stays. A specific pathophysiology involving general anesthesia and CPB-related factors (inflammation, pulmonary ischemia) has been clearly demonstrated and pulmonary atelectasis seems to play a central role in the occurence of these PPCs. The open lung approach is a ventilation strategy that aims to "open the lung and keep it open" using different ventilatory settings. The efficacy of that strategy is not demonstrated in the global surgical population. However, its application in the perioperative care of cardiac surgery patients could be of great interest by counteracting the development of atelectasis. The purpose of this multicentre, double blinded, randomized controlled study is to evaluate the influence of a perioperative multimodal protective ventilation strategy based on the "open lung approach" on postoperative outcomes during the first 7 days following cardiac surgery. Participating centres will include 500 adult patients undergoing scheduled on-pump cardiac surgery. The open lung approach will combine recruitment maneuvers (RM), positive end expiratory pressure (PEEP) at 8 cmH2O from intubation to detubation and continuation of ultraprotective ventilation during CPB. It will be compared to a conventional approach without RM, with PEEP at 2 cmH2O and discontinuation of ventilation during CPB. The primary endpoint is any post-operative pulmonary complication. The secondary endpoints are any post-operative extra-pulmonary complications and the number of ICU-free days to day 7.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02866578
Study type Interventional
Source Assistance Publique Hopitaux De Marseille
Contact
Status Completed
Phase N/A
Start date September 23, 2016
Completion date May 7, 2018
View Details
See also
  Status Clinical Trial Phase
Suspended NCT03628560 - Alternate Methodology of Pulse Oximeter Validation N/A
Recruiting NCT06139081 - Oxygen Delivery Methods of Nasal Catheter on the Incidence of Hypoxemia in Patients With Painless Gastroscopy N/A
Not yet recruiting NCT05964309 - Pre-oxygenation in Sitting Position and Oxygen Reserve Index N/A
Completed NCT00740220 - Reproducibility of 6 Minute Walk Tests for Oxygen Desaturation N/A
Completed NCT00675415 - Does Capnography Prevent Hypoxemia During Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound? N/A
Completed NCT04557605 - Effects of a Face Mask on Oxygenation During Exercise N/A
Active, not recruiting NCT05479929 - Work of Breathing Assessment in Triage Scale
Recruiting NCT05422430 - Rebreathing-induced Hypoxia and Glucose Levels N/A
Recruiting NCT03009643 - Salvage Treatment of Inhaled Nitric Oxide in Patients With Refractory Hypoxemia After Aortic Surgery N/A
Completed NCT01949012 - Capnography Monitoring During Intravenous Conscious Sedation Sedation With Midazolam for Oral Surgery N/A
Completed NCT01477450 - Comparison of Oxygen Delivery Devices for Reversal of Altitude-Induced Hypoxemia in Normal Subjects N/A
Completed NCT01470170 - Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy Phase 4
Recruiting NCT06085859 - Anesthesia Endoscope Mask is Applied to Sedation Upper Gastrointestinal Endoscopic Diagnosis and Treatment N/A
Recruiting NCT03969615 - SuperNO2VA™ and General Anesthesia Postoperative Care N/A
Completed NCT02554110 - Peripheral Nerve Stimulation to Reduce Hypoxic Events N/A
Completed NCT04998253 - Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2 Early Phase 1
Completed NCT04566419 - poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence N/A
Recruiting NCT04079465 - Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia N/A
Recruiting NCT06022523 - Accuracy of Pulse Oximeters With Profound Hypoxia N/A
Completed NCT04159116 - Prevention and Treatment of Laryngospasm and Hypoxemia Based on Risk Factors in Adult Outpatients Undergoing EGD N/A