Oxygen Supplementation & Ventilator Hyperinflation in the Endotracheal

Status Active, not recruiting

Clinical Trial Summary

This is a double crossover study where all patients are randomly allocated to one of two treatment sequences associated with endotracheal aspiration.The first treatment (A) uses two suctioning methods for each patient: one involving hyperoxygenation with administration of 100% oxygen 1 minute before and after suction (intervention I), and the other hyperoxygenation with oxygen supply to 20% above basal offer (Intervention II) in the same way.The second treatment (B) uses a technique of hyperinflation with the mechanical ventilator (PEEP-ZEEP) associated with hyperoxygenation. The intervention I, uses PEEP-ZEEP offering 20% above basal oxygenation and intervention II uses the PEEP-ZEEP with basal oxygen supply in the same way. All subjects were randomly allocated using sealed envelopes to a treatment sequence A or B on Day 1. Patients received two treatments, at least four hours apart. The first treatment is in the morning and the alternate treatment is performed in the afternoon. On Day 2 the order of the treatments was reversed using the same patient position sequence.The interventions I and II are performed at least 4 hours apart to minimize any carryover effect.

Clinical Trial Description

Endotracheal suction must be carried out only through precise indication, because it is associated with undesirable effects on the hemodynamic parameters, ventilation, oxygenation and respiratory mechanics. The hyperoxygenation is one of the methods of prevention of hypoxemia induced by tracheal suction procedure and have been proposed for its efficiency. Another method is the hyperinflation with the mechanical ventilator. Ventilator hyperinflation improves oxygenation, mobilizes the bronchial secretion excess and re-expand the lung collapsed areas. The PEEP-ZEEP is a ventilator hyperinflation technique, described as a lung inflation through a positive pressure enhancement at the end of expiration (PEEP), followed by rapid lung deflation with an abrupt reduction in the PEEP to ZEEP (0 centimeters of water (cmH2O)). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02440919
Study type	Interventional
Source	Universidade Federal de Sao Carlos
Contact
Status	Active, not recruiting
Phase	N/A
Start date	June 2013
Completion date	December 2030

View Details

See also
Status	Clinical Trial	Phase
Suspended	`NCT03628560` - Alternate Methodology of Pulse Oximeter Validation	N/A
Completed	`NCT02866578` - Open Lung Protective Ventilation in Cardiac Surgery	N/A
Recruiting	`NCT06139081` - Oxygen Delivery Methods of Nasal Catheter on the Incidence of Hypoxemia in Patients With Painless Gastroscopy	N/A
Not yet recruiting	`NCT05964309` - Pre-oxygenation in Sitting Position and Oxygen Reserve Index	N/A
Completed	`NCT00675415` - Does Capnography Prevent Hypoxemia During Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound?	N/A
Completed	`NCT00740220` - Reproducibility of 6 Minute Walk Tests for Oxygen Desaturation	N/A
Completed	`NCT04557605` - Effects of a Face Mask on Oxygenation During Exercise	N/A
Active, not recruiting	`NCT05479929` - Work of Breathing Assessment in Triage Scale
Recruiting	`NCT05422430` - Rebreathing-induced Hypoxia and Glucose Levels	N/A
Recruiting	`NCT03009643` - Salvage Treatment of Inhaled Nitric Oxide in Patients With Refractory Hypoxemia After Aortic Surgery	N/A
Completed	`NCT01949012` - Capnography Monitoring During Intravenous Conscious Sedation Sedation With Midazolam for Oral Surgery	N/A
Completed	`NCT01477450` - Comparison of Oxygen Delivery Devices for Reversal of Altitude-Induced Hypoxemia in Normal Subjects	N/A
Completed	`NCT01470170` - Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy	Phase 4
Recruiting	`NCT06085859` - Anesthesia Endoscope Mask is Applied to Sedation Upper Gastrointestinal Endoscopic Diagnosis and Treatment	N/A
Recruiting	`NCT03969615` - SuperNO2VA™ and General Anesthesia Postoperative Care	N/A
Completed	`NCT02554110` - Peripheral Nerve Stimulation to Reduce Hypoxic Events	N/A
Completed	`NCT04566419` - poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence	N/A
Completed	`NCT04998253` - Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2	Early Phase 1
Recruiting	`NCT04079465` - Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia	N/A
Recruiting	`NCT06022523` - Accuracy of Pulse Oximeters With Profound Hypoxia	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Oxygen Supplementation and Ventilator Hyperinflation in the Endotracheal Suction (OSVHES) — OSVHES

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms