Hypoxemia Clinical Trial
Official title:
Comparison of Oxygen Delivery Devices for Reversal of Altitude-Induced Hypoxemia in Normal Subjects
This study will compare the ability of pulsed-dose oxygen from a concentrator to reverse altitude-induced hypoxemia compared to compressed gas from a standard oxygen cylinder.
Subjects will be monitored non-invasively with pulse oximetry, end-tidal carbon dioxide,
tissue oxygenation and ECG. The mean seal level oxygen saturation will be recorded.Subjects
exposed to an altitude of 14,000 feet will experience moderate hypobaric hypoxia. The mean
oxygen saturation at this altitude is 83%. Subjects will receive oxygen from both an oxygen
concentrator or a cylinder of oxygen following exposure to hypobarism. Oxygen from each
source will be increased in 1 liter per minute increments until the oxygen saturation
returns to the baseline sea level oxygen saturation.
The oxygen requirement to return oxygen saturation to baseline values will be recorded. The
flow from the concentrator and the cylinder will be compared.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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