Hypovolemia Clinical Trial
Official title:
Study on Prediction of Fluid Responsiveness Using an Abdominal Compression-induced Change of Blood Pressure in Children
The purpose of this study is to evaluate predictability of an abdominal compression-induced change of blood pressure for fluid responsiveness in children.
The purpose of this study is to evaluate predictability of an abdominal compression-induced
change of blood pressure for fluid responsiveness in children.
When there are clinical signs of hypovolemia, such as hypotension, decreased urine output
and central venous pressure less than 5 mmHg, right upper abdomen is gently compressed for
10 seconds. Changes of blood pressure are continuously recorded during this period. About 3
min later, intravenous colloid fluid 10 mL/kg is infused for 20 min.
To evaluate the change of cardiac output, transesophageal or transthoracic echocardiography
is performed before and after fluid administration. In addition, hemodynamic parameters
including pulse pressure variation, systolic pressure variation, pleth variability index and
central venous pressure are also recorded before and after fluid administration.
Finally, patients will be divided into fluid responder group and non-responder group. If
cardiac output measured using echocardiography increases over 15% after fluid
administration, the patient is fluid responder. Using ROC curve, diagnostic power of
abdominal compression-induced blood pressure change for fluid responsiveness will be
evaluated.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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