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Hypovolemia clinical trials

View clinical trials related to Hypovolemia.

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NCT ID: NCT03184961 Completed - Hypovolemia Clinical Trials

Lung Recruitment Maneuver for Predicting Fluid Responsiveness in Children

Start date: June 15, 2017
Phase: N/A
Study type: Interventional

Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the changes of dynamic variables through lung recruitment maneuver could predict preload responsiveness in pediatric patients with lung protective ventilation

NCT ID: NCT03178578 Recruiting - Sepsis Clinical Trials

A Prospective Observational Study of the Expectations and Physiological Effects of Fluid Bolus Therapy

Start date: May 18, 2017
Phase:
Study type: Observational

This prospective observational study aims to (i) asses intensive care doctors trigger for and the expected physiological response to a fluid bolus and (ii) evaluate the patient's actual physiological response to a single fluid bolus at one hour post-bolus for 100 adult patients admitted to the intensive care unit will be included in the study.

NCT ID: NCT03176043 Recruiting - Hypovolemia Clinical Trials

Patient Controlled Fluid Administration

Start date: August 1, 2016
Phase: Early Phase 1
Study type: Interventional

The purpose of the study is to determine whether participants who are dictating their own administration of IV fluid boluses in response to thirst, receive better protection from hypovolaemia and volume overload than those who undergo routine fluid management. Thirst is prominent in critically ill patients and is related to dehydration. In a recent study of the symptoms experience in ITU patients at high risk of dying, the sensation of thirst was reported in 70.8% of assessments made and was considered to be one of the most intense stressors. Thirst and dehydration can be combated in an ITU setting by consuming oral fluids and through administration of intravenous fluids. However, in older adults, frailty and dysphagia reduces patients' capability to access fluid and results in thirst. In addition, the administration of IV fluids is determined by the attending physician and is often only re-evaluated on a daily or twice-daily basis. The Quench machine has been designed to allow the patient to have more control over their oral and IV fluid administration protocol. This may help reduce the sensation of thirst and dehydration in patients. The machinery is an automated fluid delivery system that will administer a given bolus of IV fluid in response to a trigger provided by the patient. The purpose of the current study is to examine the physiological basis for the functional benefit of this Quench system by investigating the effectiveness of the thirst response in healthy humans as a guide for administration of intravenous fluid boluses. To explore this, the investigators have designed a randomised, cross-over study. On one visit IV fluid boluses will be administered as per the participants' request in response to thirst. In the second arm of the study participants will be administered routine IV fluid maintenance as per NICE guidelines. Body mass at the end of a 4 hour fluid administration intervention will be our primary research outcome and will be compared between the two arms of the study. From this comparison the investigators hope to show that a patient would be able to accurately manage their level of hydration, both in terms of correcting dehydration and avoiding fluid overload. It is thought that avoiding states of fluid imbalance can reduce post surgical recovery times, reduce the incidence of post operative complications and avoid critical complications of fluid imbalance, such as acute kidney injury.

NCT ID: NCT03145935 Recruiting - Fluid Overload Clinical Trials

Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.

Start date: May 10, 2017
Phase:
Study type: Observational

Fluid overload increases morbidity and mortality of pediatrics patients in intensive care unit (ICU). It could be interesting to predict the decrease in stroke volume when diuretics are prescribed. Nevertheless, no test predict a decrease of stroke volume in a context of a diuretics induced depletion. Abdominal compression (AC) coupled with echocardiographic measurement of the stroke volume can predict fluid responsiveness and is a good tool to assess preload dependency. Another point is that during depletion refilling can occur. We aim to assess the diagnostic accuracy of abdominal compression to predict a decrease of the stroke volume of 15 % during diuretic-induced depletion of 10 ml/kg of diuresis. Secondary outcome will assess the hemoconcentration during depletion to diagnose a decrease of stroke volume during diuretic induced depletion

NCT ID: NCT03144349 Recruiting - Intensive Care Unit Clinical Trials

Diagnosis Accuracy of Hemoconcentration to Detect Hypovolemia During CRRT

Start date: December 2016
Phase:
Study type: Observational [Patient Registry]

The aim of the study is to analyze if blood protein concentration variation during continuous renal replacement therapy (CRRT) with fluid removal can predict a decrease of 15 % of cardiac index in intensive care unit (ICU) patients. Blood protein concentration, clinical data describing hemodynamic status (providing data from Pulsion medical system PiCCO2 ® monitoring), including preload dependency evaluation with passive leg raising, are collected at different times: before initiation of fluid removal, and after the first episode of hypotension or one hour after initiation of fluid removal.

NCT ID: NCT03132480 Completed - Hypovolemia Clinical Trials

Fluid Responsiveness Using Forehead Sensor in Children

forehead
Start date: June 1, 2017
Phase: N/A
Study type: Interventional

Forehead sensor can predict the more accurate fluid responsiveness than finger sensor in children

NCT ID: NCT03044405 Completed - Surgery Clinical Trials

Focused Assessed Echocardiography to Predict Fluid Responsiveness

fluidres
Start date: May 1, 2016
Phase: N/A
Study type: Interventional

The aims of the study are: 1. To evaluate the feasibility of echocardiography monitoring in postoperative unit; 2. To assess diagnostic value of different focussed echocardiography parameters to define fluid responsiveness for non-cardiac hypotensive spontaneously breathing patients after major abdominal surgery.

NCT ID: NCT03031600 Not yet recruiting - Hypovolemia Clinical Trials

Pilot Validation of a Hemodilution Technique to Estimate Blood Volume in Vivo

Start date: May 1, 2017
Phase: N/A
Study type: Interventional

The objective of this study is to determine the accuracy of estimating patient blood volume using field-expedient point-of-care measurement of hematocrit before and after hemodilution with a standardized volume of intravenous solution, in comparison to determining patient blood volume by radiodilution. A total of 33 healthy adult male subjects aged 18-35 years will undergo determination of blood volume in a fixed order: first by radiodilution, then by hemodilution. Blood volume as measured by radiodilution will be correlated with blood volume as estimated with hemodilution to assess the potential validity of hemodilution as means of estimating blood volume.

NCT ID: NCT03009305 Completed - Hypovolemia Clinical Trials

Cerebral Oximetry in Lower Body Negative Pressure

Start date: October 2015
Phase: N/A
Study type: Interventional

The study aims to describe hemodynamic effects of lower body negative pressure (LBNP). 1. If and how changes in cerebral oxygen saturation (StO2) measured by near infrared spectroscopy (NIRS) relate to changes in blood flow in the carotid arteries during progressive LBNP. 2. If and how mean systemic filling pressure (MSFP) can be measured by brief occlusion of blood flow to an arm and if this relates to LBNP-level. 3. If and how pulse pressure variations and photoplethysmographic amplitude variations during positive expiratory pressure (PEP) and continuous positive airway pressure (CPAP) relate to LBNP-level.

NCT ID: NCT02961439 Completed - Pulmonary Embolism Clinical Trials

Validation of Epworth Richmond's Echocardiography Education Focused Year

VEREEFY
Start date: November 2016
Phase: N/A
Study type: Observational

The use of echocardiography in intensive care is a developing field. In expert hands echocardiography has proven its utility in diagnosing cardiac pathology, differentiating shock states and in haemodynamic monitoring. However, whether the results obtained by experts can be generalized to trainees or specialists with limited training remains unclear. Further, concerns around training time and cost for intensive care staff have been a factor in limiting the uptake of echocardiography in intensive care. The investigators aim to assess the diagnostic accuracy of Australian ICU doctors in training after completion of the current minimum training. After completing a structured teaching program and 30 mentored training scans trainees will be assessed on their accuracy with echocardiography. In the research phase trainees will complete a further 40 scans with each one matched with an expect scan. The results from the expert and trainee scans will be compared to determine the trainee's accuracy.