Positive Pressure and Gravity Affect Volumetric Capnography

Hypoventilation Clinical Trial

Official title:

The Effect of Positive Pressure and Body Position on Volumetric Capnography Assessed by Electrical Impedance Tomography

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03853057
• Other study ID #: 04112014
• Status: Completed
• Phase: N/A
• Start date: February 1, 2016
• Est. completion date: February 21, 2019

Study information

• Verified date: February 2016
• Source: Hospital Privado de Comunidad de Mar del Plata
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Volumetric capnography is an interesting and non-invasive tool for monitoring ventilation in mechanically ventilated patients. The aim of this study was to test the effect of positive pressure ventilation and different body positions on volumetric capnograms.

Description:

In this interventional study awake and healthy volunteers will be submitted to spontaneous, pressure support and control pressure ventilation using a tight nasal mask. Volumetric capnography and electrical impedance tomography (EIT) will be continuously recorded during the protocol. Different body positions were randomly tested. Analysis of global and regional distribution of ventilation using EIT will be matched with changes observed in volumetric capnography-derived parameters.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: February 21, 2019
• Est. primary completion date: February 21, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 28 Years to 39 Years

Eligibility

Inclusion Criteria:

• American Society Anesthesia physical status I.

• Age between 25-39 years old,

• Body mass index between 23-28 kg/m2,

• Non-smokers.

Exclusion Criteria:

• Presence of pulmonary or cardiac diseases.

• Abnormal spirometry.

Related Conditions & MeSH terms

• Hypoventilation

Intervention

Other:
• body positions
positive pressure ventilation at different body positions

Locations

Country	Name	City	State
Argentina	Hospital Privado de Comunidad	Mar del Plata	Buenos Aires

Sponsors (1)

Lead Sponsor	Collaborator
Hospital Privado de Comunidad de Mar del Plata

Country where clinical trial is conducted

Argentina, 

References & Publications (2)

Costa EL, Lima RG, Amato MB. Electrical impedance tomography. Curr Opin Crit Care. 2009 Feb;15(1):18-24. Review. — View Citation

Tusman G, Scandurra A, Böhm SH, Suarez-Sipmann F, Clara F. Model fitting of volumetric capnograms improves calculations of airway dead space and slope of phase III. J Clin Monit Comput. 2009 Aug;23(4):197-206. doi: 10.1007/s10877-009-9182-z. Epub 2009 Jun 11. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Analysis of the changes in volumetric capnographic parameters with changes in body positioning and positive pressure ventilation.	The volunteers are breathing spontaneously with and without positive pressure support. Capnographic parameters were registered at each studied condition.	4 hours
Secondary	Electrical impedance images of the distribution of ventilation with changes in body positioning and positive pressure ventilation.	The volunteers are breathing spontaneously with and without positive pressure support. Electrical impedance images were taken at each studied condition.	4 hours