Hypothermia Clinical Trial
Official title:
Histones and Free-plasma DNA in the Days Following the Cardiac Arrest
Verified date | June 2017 |
Source | University of Aarhus |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.
Status | Completed |
Enrollment | 42 |
Est. completion date | September 2016 |
Est. primary completion date | June 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Out of hospital cardiac arrest of presumed cardiac cause - Return of spontaneous circulation (ROSC) - Glasgow Coma Score < 8 - Age > 18 years and < 80 years Exclusion Criteria: - >60 minutes from the circulatory collapse to ROSC - Time interval > 4 hours from cardiac arrest to initiation of targeted temperature management - Terminal illness - Coagulation disorder - Unwitnessed asystolia - Cerebral performance category 3-4 before the cardiac arrest - Severe persistent cardiogenic shock - Pregnancy - Persistent cardiogenic shock (systolic blood pressure < 80 despite inotropic treatment) - New apoplexy or intracerebral hemorrhage - Lack of consent from the relatives - Lack of consent from the general practitioner - Lack of consent from the patient if he/she wakes up and is relevant |
Country | Name | City | State |
---|---|---|---|
Denmark | Dept of Anesthesiology and Intensive Care and Dept of Clinical Biochemistry, Aarhus University Hospital | Aarhus | Aarhus N |
Lead Sponsor | Collaborator |
---|---|
University of Aarhus |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Simplified Acute Physiology Score (SAPS) score | Approximate 24 hours, 48 hours and 72 hours after cardiac arrest | ||
Other | Platelet count | Approximate 24 hours, 48 hours and 72 hours after cardiac arrest | ||
Primary | Plasma histones | The level of plasma histones | Approximate 24 hours after cardiac arrest | |
Primary | Free-plasma DNA | The level of total free-plasma DNA | Approximate 24 hours after cardiac arrest | |
Secondary | Plasma histones | The level of plasma histones | Approximate 48 hours and 72 hours after cardiac arrest | |
Secondary | Free-plasma DNA | The level of total free plasma DNA | Approximate 48 hours and 72 hours after cardiac arrest |
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