Clinical Trial Details
— Status: Recruiting
Administrative data
| NCT number |
NCT04208594 |
| Other study ID # |
123 |
| Secondary ID |
|
| Status |
Recruiting |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
December 11, 2019 |
| Est. completion date |
May 2020 |
Study information
| Verified date |
December 2019 |
| Source |
Alexandria University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
50 Patients, aged from 18 to 39 years, ASA physical status I and II, undergoing endoscopic
sinus surgery will be enrolled in the study.The patients will be randomly allocated by simple
randomization using a computer programme into two groups by closed envelope technique (having
25 patients in each group): GROUP (P): will receive oral propranolol (INDERAL® -propranolol
hydrochloride Ph. Eur. 10mg manufactured by AstraZeneca Egypt under license of AstraZeneca
UK), 10 mg one tablet at 8:00 pm in the evening before the day of the surgery and one 10 mg
tablet one hour before the induction of anesthesia.
GROUP (I): will receive oral ivabradine (Procoralan® 5mg manufactured by Servier
laboratories, France), 5 mg one tablet at 8:00 pm in the evening before the day of the
surgery and one 5 mg tablet one hour before the induction of anesthesia.
Description:
Aim of the work To compare efficacy of oral premedication with ivabradine versus propranolol
before hypotensive anesthesia with nitroglycerin during endoscopic sinus surgery on reduction
of reflex tachycardia.
Secondary aim:
- Compare the safety and incidence of side effects between both drugs.
- Compare the amount of nitroglycerin used, and blood loss between both drugs during
endoscopic sinus surgery.
Patients and methods This study will be conducted in the Department of Anesthesia, ENT
operating theater, Alexandria University Hospitals after being approved by the Departmental
Research and Ethical Committee, and after obtaining informed consents from all patients.
50 Patients, aged from 18 to 39 years, ASA physical status I and II, undergoing endoscopic
sinus surgery will be enrolled in the study.
Exclusion Criteria:
- Patients with cardiovascular disease (hypertension, congestive heart failure, and
coronary artery disease).
- Patients on beta-blockers.
- Patients with the base line heart rate<60 beats per minute.
- Patients with diabetes mellitus (DM).
- Cerebrovascular insufficiency.
- Coagulation defects.
- History of renal or hepatic insufficiency.
- Hypersensitivity to the study drugs.
- Patients with history of bronchial asthma
The patients will be randomly allocated by simple randomization using a computer programme
into two groups by closed envelope technique (having 25 patients in each group):
GROUP (P): will receive oral propranolol (INDERAL® -propranolol hydrochloride Ph. Eur. 10mg
manufactured by AstraZeneca Egypt under license of AstraZeneca UK), 10 mg one tablet at 8:00
pm in the evening before the day of the surgery and one 10 mg tablet one hour before the
induction of anesthesia.
GROUP (I): will receive oral ivabradine (Procoralan® 5mg manufactured by Servier
laboratories, France), 5 mg one tablet at 8:00 pm in the evening before the day of the
surgery and one 5 mg tablet one hour before the induction of anesthesia.
Preoperative screening of all patients will include:
1. Demographic data (age, sex).
2. Detailed medical history.
3. Complete physical examination.
4. Routine laboratory investigations:
- Complete blood picture.
- Bleeding time and coagulation time.
- Prothrombin time and activated partial thromboplastin time.
- Liver enzymes: alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
- Serum bilirubin (total and direct).
- Blood urea and serum creatinine.
- Fasting blood sugar.
5. Chest X-ray.
6. Standard 12 leads electrocardiogram.
Anesthesia:
• All patients will receive the same anesthetic technique.
- Premedication will be standardized for all patients and consists of oral diazepam 5 mg
the night before surgery.
- On arrival to operating room, intravenous line will be cited and lactated ringer
solution will be infused 4-6 ml/kg/h.
- Before induction of general anesthesia (GA), all patients will be monitored with:
- None-invasive blood pressure (NIBP).
- Electrocardiograph (ECG).
- Pulse oximeter (SpO2).
- After induction of GA, all patients will be monitored with:
- Capnography for end-tidal CO2 (ETCO2).
- Radial artery cannula (G20) for intra-arterial blood pressure monitoring after
performing Allen's test.
- Peripheral nerve stimulator (PNS) will be applied on the ulnar nerve for neuromuscular
blockade.
Induction and maintenance of anesthesia:
- Anesthesia Will be induced with propofol 2mg/kg iv, fentanyl 1 μg/kg iv and
cisatracurium besylate 0.15 mg/kg iv, when TOF count showed disappearance of T1 (0/4)
endotracheal intubation with appropriate size will be accomplished and lungs will be
mechanically ventilated to maintain the ETCO2 30-35 mmHg.
- Anesthesia will be maintained with inspired isoflurane 1.5 % and cisatracurium besylate
top up doses 0.03 mg/kg/30 min will be given guided with TOF count aiming to keep it as
1/4. Airway will be secured by oro-pharyngeal packing and patients will be positioned
supine with head up 30°. Dexamethasone 0.2 mg/kg and metoclopramide 10 mg slowly iv will
be given as emesis prophylaxis.
- Deliberate hypotension will be induced until completion of the main surgical procedures
to achieve a MAP within the target range of 55‒65 mm Hg (approximately 30% below a
patient's usual MAP), nitroglycerin (1mg/ml) with a dose range 5-20 mcg/min will be
added if needed.
- All patients will be operated upon by the same surgical team.
- Bleeding in the surgical field and the quality of the visibility will be assessed
subjectively by the surgeon who will be blinded to the infused drug using 6 points scale
adapted by Boezaart et al.(25):
- 0= no bleeding.
- 1= slight bleeding so blood evacuation not necessary.
- 2= slight bleeding so sometimes blood has to be evacuated.
- 3= low bleeding so blood has to be often evacuated and operative field is visible for
some seconds after evacuation.
- 4= average bleeding so blood has to be often evacuated, and operative field is visible
only right after evacuation.
- 5= high bleeding so constant blood evacuation is needed, sometimes bleeding exceeds
evacuation and surgery is hardly possible.
The 1st assessment will be 30 min after the beginning of surgery and then every 30 min till
the end of surgery.
- As an objective method, the volume of fluid aspirated from the surgical field during
surgery will be also measured.
- When blood loss exceed 300 mL, 6% hydroxyethyl starch solutions (Voluven, Fresinius
Kabi, Bad Homberg, Germany) will be administered at a 1:1 ratio, and if hematocrit is
<27%, a transfusion will be initiated .
- Hypotension (MAP<55 mm Hg) will be treated with ephedrine 15 mg intravenous.
- Bradycardia (HR˂ 50) will be recorded and managed with atropine 0.02mg/kg.
- With termination of surgery, isoflurane will be discontinued, the oropharyngeal pack
will be removed and the oropharynx will be suctioned under direct vision using the rigid
laryngoscope. The residual cisatracurium will be reversed with neostigmine 0.05 mg/kg iv
and atropine 0.02 mg/kg iv when the TOF count is 2/4, trachea will be extubated once the
patients showed eye opening and purposeful movement and then patients will be
transferred to PACU where BP, SpO2 and ECG will be monitored. O2 supplementation will be
provided via face mask.
Measurements:
The following parameters will be measured and will be statistically analyzed between the two
studied groups:
1. Demographic data (age and sex).
2. Hemodynamic variables:
- Mean arterial blood pressure (MABP) in mmHg by invasive monitoring using GE monitor
.
- Heart rate: (beats / minute) using GE monitor.
Time Points for Hemodynamic Parameter Measurements:
- Baseline before induction of anesthesia.
- Before starting the infusion of NTG (baseline)
- 5 minutes after initiation of NTG
- Every 30 min throughout deliberate hypotension till termination of NTG infusion.
- 5 minutes after the end of deliberate hypotension
- Immediately after extubation in the operating room
- 60 min after extubation in the PACU
3. The amount of nitroglycerin used:
- Duration of DH (min(
- NTG amounts during DH (μg/kg/min).
4. Blood loss and need for blood transfusion:
- Intraoperative bleeding (mL).
- Intraoperative autologous blood transfusion (units of packed RBCs).
5. Total urine output (mL).
6. Laboratory investigations:
- Random blood sugar (RBS)
- Serum lactate level. Both will be measured immediately after induction of
anesthesia, and after discontinuation of deliberate hypotension (NTG infusion).
7. Duration of surgery (the time from start of surgical intervention till its end) (min.).
8. Patients administered ephedrine during DH (n).
9. Events of bradycardia (frequency).
10. Complications need intervention such as bronchospasm, laryngospasm, or vomiting will be
recorded and managed.
