Tapse/Pasp General Anesthesia

Hypotension Clinical Trial

Official title:

Prediction of TAPSE/PASP Ratio for Hypotension Due to General Anesthesia Induction

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06414811
• Other study ID #: 2024-44
• Status: Not yet recruiting
• Start date: May 15, 2024
• Est. completion date: March 15, 2025

Study information

• Verified date: May 2024
• Source: Aydin Adnan Menderes University
• Contact: ferdi gülasti
• Phone: +905054929650
• Email: ferdigulasti[@]gmail.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

TAPSE, one of the methods for evaluating right ventricular systolic function; It is a bar parameter that can easily measure apex-basal shortening and provides specific information about global RV function. TAPSE/PASP can be calculated as load-independent parameters to evaluate RV function. Because RV function is sensitive to change in afterload, known as the RV-pulmonary circulation (PC) connection.

This study aims to identify patients who are candidates for hypotensive events due to general anesthesia in a hemodynamically stable population.

Description:

TAPSE, one of the methods for evaluating right ventricular systolic function; It is a bar parameter that can easily measure apex-basal shortening and provides specific information about global RV function. TAPSE/PASP can be calculated as load-independent parameters to evaluate RV function. Because RV function is sensitive to change in afterload, known as the RV-pulmonary circulation (PC) connection.

This study aims to identify patients who are candidates for hypotensive events due to general anesthesia in a hemodynamically stable population.

Patients will be measured by transthoracic echocardiography in the preoperative period, 15-30 minutes before induction.

Basal hemodynamic parameters and non-invasive and/or hemodynamic values will be recorded every two minutes after induction until surgical incision.Patients with a 30% decrease in SBP from the baseline and a decrease in MAP below 65 mmHg in the first 10 minutes after anesthesia induction will be considered to have hypotension. Patients will be divided into 2 groups: 'with' and 'without' hypotension.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 52
• Est. completion date: March 15, 2025
• Est. primary completion date: January 15, 2025
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

1. Written informed consent;

2. 18-75 years old

3. ASA Physical Status 1-3;

4. Patients planned for surgery

Exclusion Criteria:

1. The patient is pregnant

2. After cardiac surgery

3. Severe pulmonary hypertension

4. Severe valve disease

5. Hypertrophic or dilated cardiomyopathy

6. Presence of acute myocardial infarction

7. Patients with severe visual or hearing impairment/disability

8. ASA physical status IV or V

9. Ischemic heart disease, conduction disorder.

Related Conditions & MeSH terms

• Hypotension

Intervention

Other:
• HYPOTENSION
MAP below 55 mmHg or long-term (2 minutes or more) hypotensive attacks will be treated with ephedrine 0.1mg/kg.

Locations

Country	Name	City	State
Turkey	Ferdi Gülasti	Aydin

Sponsors (1)

Lead Sponsor	Collaborator
Aydin Adnan Menderes University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	1. tension	Intraoperative systolic arterial tension, diastolic arterial tension and mean arterial tension will be taken and recorded for the patients.	4-5 hours]