Hypotension Clinical Trial
Official title:
Norepinephrine Versus Ephedrine for Treatment of Hypotension During Spinal Anesthesia for Caesarean Section
Prospective, randomized study, including full term parturients scheduled for caesarean section under spinal anesthesia. Spinal anesthesia was performed in sitting position with a 25 G spinal needle and all patients received 15 ml/kg of crystalloid intravenously during the spinal block. Baseline hemodynamics: heart rate, systolic and diastolic blood pressure were recorded before spinal anesthesia and intraoperatively. Postspinal hypotension, defined as decrease of Systolic blood pressure>20% from the baseline value, was managed using Ephedrine increments 6 mg/3min in patients of GE group or by 5 mcg Norepinephrine/3min for the patients of GN group. Intraoperative hemodynamic data of the 2 groups were compared.
Prospective, randomized study including full term parturients scheduled for caesarean
section under spinal anesthesia. All patients were ASA status I/II and patients with
arrhythmia were excluded. Spinal anesthesia was performed in sitting position at L3-4 or
L4-5. A 25 G spinal needle was used for intrathecal injection of 8 mg of hyperbaric
bupivacaine, 2.5 mcg sufentanil and 100 mcg morphine. All patients received 15 ml/kg of
crystalloids intravenously during the spinal block. Patients were positioned in left lateral
tilt position. Baseline hemodynamics; HR, systolic (SBP) and diastolic blood pressure (DPB)
were recorded before spinal anesthesia and intraoperatively (every 2 min). Post anesthesia
hypotension was defined as decrease of SBP>20% from the baseline value. If hypotension
occurred, patients were randomized into 2 groups:
- GE group in which hypotension were managed using ephedrine increments of 6 mg Ephedrine
every 3 min until correction of SBP
- GN group: patients of this group received 5mcg of Norepinephrine/3 min demographic and
hemodynamic data of the two groups were compared.
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