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NCT03065309 Clinical Trial

Determination of Remifentanil's ED50 for Rapid Sequence Intubation Avoiding Bradycardia and Hypotension in Adults

Hypotension Clinical Trial

Official title:
Determination of Remifentanil's ED50 for Rapid Sequence Intubation Avoiding Bradycardia and Hypotension in Adults

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03065309
Other study ID # TCC-Lara-2017
Secondary ID
Status Completed
Phase Phase 3
First received February 22, 2017
Last updated September 12, 2017
Start date February 25, 2017
Est. completion date March 1, 2017

Study information
Verified date September 2017
Source Brasilia University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study will find the median effective dose of remifentanil for rapid sequence intubation which avoids bradycardia and hypotension

Description:

Remifentanil is becoming popular for rapid sequence intubation because it has a fast onset and ultra-short half-life.

Remifentanil a potent opioid associated to bradycardia and hypotension at high doses.

Recruitment information / eligibility
Status Completed
Enrollment 15
Est. completion date March 1, 2017
Est. primary completion date February 28, 2017
Accepts healthy volunteers No
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Indication of anesthesia induction

Exclusion Criteria:

- Protocol violation

- Monitoring problems

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Remifentanil
bolus dose

Locations
Country Name City State
Brazil Hospital das Forças Armadas Brasilia Distrito Federal

Sponsors (1)
Lead Sponsor Collaborator
Brasilia University Hospital

Country where clinical trial is conducted

Brazil, 

Outcome
Type Measure Description Time frame Safety issue
Primary hemodynamic stability during rapid sequence intubation no bradycardia and no hypotension from anesthesia induction up to 5 minutes
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