Hypotension Clinical Trial
Official title:
Up-Down Determination of the ED90 of Metaraminol to Treat Hypotension During Elective Cesarean Section
The purpose of this study is to find the best dose of metaraminol to be used in patients during elective cesarean sections.
The purpose of this study is to determine the effective dose 90% (ED90) of metaraminol to
treat hypotension after spinal anesthesia in elective cesarean sections (CS). It is a
double-blind study that uses the biased-coin up-down sequential allocation method to
determine the ED90 of metaraminol.
Baseline systolic blood pressure (SBP) will be determined by three automated measures 3
minutes apart just before CS. During the period from induction of spinal anesthesia to fetal
delivery SBP will be monitored every minute and metaraminol will be administered every time
it is lower than baseline value. If SBP falls below 80% of baseline value, the treatment
will be considered a failure. An adequate response will be defined as the absence of
hypotension during the study period.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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