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Hypotension clinical trials

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NCT ID: NCT04865614 Completed - Blood Pressure Clinical Trials

Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair

COMPETENT
Start date: April 1, 2019
Phase:
Study type: Observational

The induction of anaesthesia is one of the most critical situations for high-risk-patients undergoing interventions surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this phase. This retrospective cohort study aims to find out if the choice of the induction agent has a major impact on blood pressure and the use of catecholamines during the induction and the interventional procedure in patients undergoing interventional mitral valve repair.

NCT ID: NCT04858178 Completed - Clinical trials for Spinal Cord Injuries

Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes

Start date: February 17, 2022
Phase: N/A
Study type: Interventional

This study looks to characterize autonomic nervous system dysfunction after spinal cord injury and identify the potential role that transcutaneous spinal cord stimulation may play at altering neuroregulation. The autonomic nervous system plays key parts in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with spinal cord injury typically encounter complications. For both individuals with spinal cord injury and uninjured controls, experiments will utilize multiple parallel recordings to identify how the autonomic nervous system is able to inhibit and activate sympathetic signals. The investigators anticipate that those with autonomic dysfunction after spinal cord injury will exhibit abnormalities in these precise metrics. In both study populations, transcutaneous spinal cord stimulation will be added, testing previously advocated parameters to alter autonomic neuroregulation. In accomplishing this, the investigators hope to give important insights to how the autonomic nervous system works after spinal cord injury and if it's function can be improved utilizing neuromodulation.

NCT ID: NCT04850092 Completed - Hypotension Clinical Trials

Dynamic Arterial Elastance to Predict Postural Change Induced Hypotension

Start date: December 15, 2021
Phase:
Study type: Observational

During general anesthesia, hypotension might occur during positional change. It is reported that hypotension after positional change from supine to prone is mainly caused by the decrease in preload. The investigators aimed to investigate whether dynamic arterial elastance might predict hypotension associated with positional change from supine to prone.

NCT ID: NCT04803903 Completed - Clinical trials for Hypotension During Surgery

HPI Index With GDHT in Predicting Hypotension In General Anesthesia Patients

Start date: November 5, 2018
Phase:
Study type: Observational

The study will investigate whether the use of Goal Directed Hemodynamic Therapy implemented with the HPI algorithm using a treatment algorithm will reduce the incidence of hypotension and improve treatment of hypotension.

NCT ID: NCT04789330 Completed - Surgery Clinical Trials

Norepinephrine vs Phenylephrine During General Anesthesia

VEGA-1
Start date: July 1, 2021
Phase: Phase 4
Study type: Interventional

50 million patients undergo surgery each year in the United States. Postoperative mortality is considered the third leading cause of death worldwide. Hypotension during surgery have been linked to increased postoperative morbidity and mortality. Episodes of hypotension during surgery are associated with an increased risk of acute kidney injury, stroke, cardiac events and death. Treating or preventing hypotension during general anesthesia and major surgery was found to improve outcomes. At this time, it is unclear what is the best vasopressor to maintain blood pressure during surgery under general anesthesia. With this pilot pragmatic trial, the investigators will explore the impact of norepinephrine (NE) or phenylephrine (PE) on post-operative events in patients undergoing major surgery with general anesthesia and needing vasopressors infusion to maintain their systemic arterial pressure.

NCT ID: NCT04789005 Completed - Clinical trials for Spinal Induced-hypotension

Comparison of Phenylephrine and Norepinephrine for Spinal-induced Hypotension

Start date: November 10, 2019
Phase: Phase 3
Study type: Interventional

Hypotension after spinal anaesthesia for cesarean deliveries is frequently encountered. Phenylephrine an α-agonist is commonly used for the prevention and treatment of spinal-induced hypotension. Phenylephrine causes baroreceptor-mediated bradycardia leading to subsequent reduction in cardiac output. Preservation of heart rate and cardiac output is important in high-risk conditions such as placental insufficiency, fetal distress and maternal cardiac disease. Recently, norepinephrine has been found as effective as phenylephrine in treatment of spinal induced hypotension. When norepinephrine is used as a bolus, it is effective at maintaining blood pressure while also conferring a greater heart rate and cardiac output compared to phenylephrine.

NCT ID: NCT04780139 Completed - Clinical trials for Post-spinal Anesthesia Hypotension

Ultrasonographic Evaluation of Internal Jugular Vein Cross Sectional Area for Prediction of Post Spinal Hypotension

Start date: March 1, 2021
Phase:
Study type: Observational

The aim of this study is to evaluate the efficacy of internal jugular cross sectional area for predicting the occurrence of PSAH.

NCT ID: NCT04775576 Completed - Clinical trials for Perioperative/Postoperative Complications

Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation

Start date: February 25, 2021
Phase: N/A
Study type: Interventional

This study aims to compare the volume management methods performed by using conventional method and PVI monitoring in intraoperative fluid treatment during bilateral salpingo-oophorectomy and total hysterectomy operation.

NCT ID: NCT04752904 Completed - Hypotension Clinical Trials

Noninvasive Continuous Blood Pressure Monitoring for Cesarean Delivery

Start date: April 27, 2021
Phase: N/A
Study type: Interventional

Noninvasive continuous blood pressure monitoring for preventing post-spinal hypotension during cesarean delivery: A randomized controlled trial

NCT ID: NCT04750486 Completed - Labor Pain Clinical Trials

Lower Limb Compression Prevents Hypotension After Epidural in Labor

Start date: February 5, 2021
Phase: N/A
Study type: Interventional

The goal of this study is to determine whether the use of sequential compression devices (lower limb compression) can reduce the rate of maternal hypotension after epidural, and therefore reduce the incidence of fetal heart tracing complications during labor.