Hypotension on Induction Clinical Trial
Official title:
Prediction of Hypotension After Induction of General Anesthesia Using Wearable Carotid Artery Doppler Ultrasound Patch in Adult Patients Undergoing Elective Noncardiac Surgery: a Prospective Observational Study
This study is being conducted to find out if a special device called FloPatch™, which sticks to a persons skin and uses ultrasound to check the blood flow in their neck, can tell if someone going to have low blood pressure after they get put to sleep for surgery. The investigators will be testing this in adults who are having elective non-heart surgery. Basically, the goal is to see if this device can help predict who might have low blood pressure during surgery. Hypotension is a common side-effect of general anesthesia induction, and is related to adverse outcomes, including significantly increasing risk of one-year mortality. Even short durations of intraoperative hypotension have been associated with acute kidney injury (AKI) and myocardial injury. Myocardial injury after non-cardiac surgery (MINS) is a common postoperative complication associated with adverse cardiovascular outcomes, and intraoperative hypotension is believed to be involved in its development. In the preoperative setting, a systematic review of 50 studies (2,260 patients) evaluating techniques to assess adult patients with refractory hypotension or signs of organ hypoperfusion found that half of all patients were fluid-responsive, pointing to volume status as a significant risk factor, while also presenting a challenge in distinguishing fluid-responders from non-responders. For surgical patients, preoperative fasting, hypertonic bowel preparations, anesthetic agents, and positive pressure ventilation all contribute to reduced effective circulating blood volume. Optimized fluid therapy remains the cornerstone of treatment of hypovolemia, with excellent effectiveness. Since the liberal use of fluids may result in fluid overload, which is associated with the development of pulmonary edema, wound infection, postoperative ileus, and anastomotic leakage, it is imperative to identify those patients who may benefit from it. The hypothesis is that the corrected Flow Time (cFT) measured by the FloPatch will help predict hypotension after the induction of general anesthesia.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05497700 -
Comparative Efficacity of Ephedrine Versus Norepinephrine to Correct Anesthesia Induction Related Hypotension
|
Phase 3 | |
| Not yet recruiting |
NCT03580590 -
Efficacy of Oral Diltiazem on the Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
|
Early Phase 1 | |
| Completed |
NCT04573842 -
Ultrasound Assessment of the Subclavian Vein for Predicting Hypotension in Children After Anaesthesia Induction
|
||
| Recruiting |
NCT06426784 -
Perfusion Index as a Predictor of Hypotension Following Sub-arachnoid Block Among Patients Undergoing Lower Segment Caesarean Section
|
||
| Completed |
NCT04603469 -
Hypotension in Children With Down Syndrome With Anesthesia Induction
|
||
| Recruiting |
NCT05891951 -
Effect of Carotid Ultrasound-guided Fluid Management on Anesthetic-induced Hypotension in Elderly Patients Undergoing Gastrointestinal Surgery
|
N/A | |
| Completed |
NCT05842759 -
Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study
|
N/A | |
| Recruiting |
NCT05884918 -
Intraoperative Hypotension in High-risk Patients Undergoing Surgery
|
||
| Completed |
NCT05239234 -
Ultrasonographic Predictors of Hypotension After Induction
|
||
| Not yet recruiting |
NCT04291794 -
Mean Arterial Pressure Reduction Anesthesia Induction Using Propofol Bolus or Tritiated Target-infusion
|
Phase 4 | |
| Completed |
NCT04051073 -
Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study.
|
Phase 3 | |
| Completed |
NCT01669434 -
Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery
|
Phase 4 | |
| Completed |
NCT05424510 -
PoCUS Guided Fluids to Prevent Post-induction Hypotension
|
N/A | |
| Recruiting |
NCT05969886 -
Ventricular-Arterial Coupling: A Predictor of Post-Induction Hypotension
|
||
| Not yet recruiting |
NCT05536323 -
Bolus Versus Continuous Remimazolam for Anesthetic Induction
|
N/A | |
| Recruiting |
NCT03237429 -
The Relationship Between BCM, Arterial Stiffness and Hemodynamic Instability During Induction of General Anesthesia
|
||
| Withdrawn |
NCT04299776 -
CirQPOD Shoulder Study
|
N/A | |
| Completed |
NCT03439007 -
Anesthesia-induced Hypotension and Fluid Responsiveness
|
||
| Completed |
NCT03787732 -
Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation
|
Phase 4 | |
| Not yet recruiting |
NCT05960604 -
Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
|