Hypotension on Induction Clinical Trial
Official title:
Perfusion Index as a Predictor of Hypotension Following Propofol Induction of General Anesthesia in Geriatric Patients - A Prospective Observational Study.
The influence of hemodynamic aberrations during anesthesia on adverse outcomes is an important clinical issue. There is evidence that hypotension and hypertension during general anesthesia are independently associated with adverse outcomes in patients having both noncardiac and cardiac surgery.One of the intervals of general anesthesia during which hypotension is prevalent is the period after the induction of anesthesia but before the onset of surgical stimulation. This period is particularly prone to decreased vigilance with regard to hemodynamic changes. Statistically significant predictors of hypotension 0-10 min after anesthetic induction included: ASA III-V, baseline MAP <70 mm Hg, age > or =50 years, the use of propofol for induction of anesthesia, and increasing induction dosage of fentanyl.While the potential preoperative factors associated with hypotension 5-10 min after the induction of anesthesia in patients with ASA I-II included baseline MAP 70 mm Hg, age > 50 years, use of propofol during induction, and magnitude of fentanyl dose during induction. Perfusion index (PI) is a relatively new parameter estimating the pulsatility of blood in the extremities, calculated using infrared spectrum as part of plethysmography waveform processing. It is a simple,cost-effective and non-invasive method of assessing peripheral perfusion determined by the percentage of pulsatile to non-pulsatile blood flow in the extremities. PI indicates the status of the microcirculation which is densely innervated by sympathetic nerves, and therefore, is affected by multiple factors responsible for vasoconstriction or vasodilatation of the microvasculature.It is an indicator of systemic vascular resistance (SVR). PI is said to be useful in monitoring depth of anesthesia, hypothermia, successful epidural placement in parturients, adequate relief from ureteric obstruction, response to fluid therapy in critically ill and intraoperative patients and adequacy of circulation in newborn.The value of PI is inversely related to the vascular tone, though not in a linear fashion. Therefore, vasodilatation reflecting higher baseline PI has been associated with reductions in blood pressure (BP) following spinal anesthesia.The resting SVR can influence incidence and severity of post-spinal hypotension in parturients. It has been established that a positive correlation between pre-anesthetic plethysmographic variability index (PVI) and reduction in BP following induction of anesthesia using propofol in healthy adults, that is, higher PVI was associated with more mean arterial pressure (MAP) reductions. Similarly, a significant proportion of hypotension after induction of anesthesia with propofol can be attributed to the baseline SVR. Mehandale SG. and Rajasekhar P. underwent A prospective observational study on fifty adults for the use of Perfusion index as a predictor of hypotension following propofol induction and revealed that a baseline PI <1.05 predicted incidence of hypotension at 5 min with sensitivity 93%, specificity 71%, positive predictive value (PPV) 68% and negative predictive value (NPV) 98%. the hypothesised was that it is possible to define a threshold baseline value of PI that predicts hypotension based on individual's pre-induction SVR in patients > 65 years old following anesthetic induction with propofol and fentanyl as multifactorial risk for postinduction hypotension. Outcomes: A cut-off value of baseline PI below which hypotension at 5 min post induction could be predicted will be the primary outcome, while positive and negative predictive values at 15 minutes will be secondary outcomes.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05497700 -
Comparative Efficacity of Ephedrine Versus Norepinephrine to Correct Anesthesia Induction Related Hypotension
|
Phase 3 | |
Not yet recruiting |
NCT03580590 -
Efficacy of Oral Diltiazem on the Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
|
Early Phase 1 | |
Completed |
NCT04573842 -
Ultrasound Assessment of the Subclavian Vein for Predicting Hypotension in Children After Anaesthesia Induction
|
||
Recruiting |
NCT06426784 -
Perfusion Index as a Predictor of Hypotension Following Sub-arachnoid Block Among Patients Undergoing Lower Segment Caesarean Section
|
||
Completed |
NCT04603469 -
Hypotension in Children With Down Syndrome With Anesthesia Induction
|
||
Recruiting |
NCT05891951 -
Effect of Carotid Ultrasound-guided Fluid Management on Anesthetic-induced Hypotension in Elderly Patients Undergoing Gastrointestinal Surgery
|
N/A | |
Completed |
NCT05842759 -
Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study
|
N/A | |
Recruiting |
NCT05884918 -
Intraoperative Hypotension in High-risk Patients Undergoing Surgery
|
||
Completed |
NCT05239234 -
Ultrasonographic Predictors of Hypotension After Induction
|
||
Not yet recruiting |
NCT04291794 -
Mean Arterial Pressure Reduction Anesthesia Induction Using Propofol Bolus or Tritiated Target-infusion
|
Phase 4 | |
Completed |
NCT04051073 -
Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study.
|
Phase 3 | |
Completed |
NCT01669434 -
Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery
|
Phase 4 | |
Completed |
NCT05424510 -
PoCUS Guided Fluids to Prevent Post-induction Hypotension
|
N/A | |
Recruiting |
NCT05969886 -
Ventricular-Arterial Coupling: A Predictor of Post-Induction Hypotension
|
||
Not yet recruiting |
NCT05536323 -
Bolus Versus Continuous Remimazolam for Anesthetic Induction
|
N/A | |
Recruiting |
NCT03237429 -
The Relationship Between BCM, Arterial Stiffness and Hemodynamic Instability During Induction of General Anesthesia
|
||
Withdrawn |
NCT04299776 -
CirQPOD Shoulder Study
|
N/A | |
Completed |
NCT03439007 -
Anesthesia-induced Hypotension and Fluid Responsiveness
|
||
Completed |
NCT03787732 -
Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation
|
Phase 4 | |
Not yet recruiting |
NCT05960604 -
Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
|