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Hypoplastic Left Heart Syndrome clinical trials

View clinical trials related to Hypoplastic Left Heart Syndrome.

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NCT ID: NCT04181255 Terminated - Clinical trials for Congenital Heart Disease

Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy

Start date: February 25, 2020
Phase: Phase 1
Study type: Interventional

This clinical trial is being done to see if giving surfactant (Curosurf®) will decrease the number of days that infants will need a breathing tube, decrease the days in the critical care unit and decrease the number of days needed in the hospital. The primary hypothesis for this study is that there will be fewer days needed on mechanical ventilation and improved lung compliance and pulmonary gas exchange.

NCT ID: NCT04090697 Terminated - Clinical trials for Congenital Heart Disease

Use of Oxandrolone to Promote Growth in Infants With HLHS

Start date: December 20, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The primary aim of this study is to determine if clinically relevant doses of buccally administered oxandrolone are safe and tolerable in neonates with hypoplastic left heart syndrome (HLHS) or other single right ventricular anomalies who have undergone a Norwood procedure. The secondary aim is to evaluate the efficacy of buccally administered oxandrolone in improving objective indices of growth and nutrition in neonates who have undergone a Norwood procedure.

NCT ID: NCT02398604 Terminated - Clinical trials for Hypoplastic Left Heart Syndrome

Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome

ELPIS
Start date: April 2015
Phase: Phase 1
Study type: Interventional

This study is intended to evaluate the safety and feasibility of intramyocardial injection of allogeneic mesenchymal cells during the Bi-Directional Cavopulmonary Anastomosis (BDCPA) surgery for hypoplastic left heart syndrome (HLHS) pediatric patients.

NCT ID: NCT01445041 Terminated - Clinical trials for Hypoplastic Left Heart Syndrome

Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome

Start date: September 1, 2011
Phase: Phase 1
Study type: Interventional

Further study details as provided by Duke University: Purpose: To evaluate the feasibility and safety of collecting and infusing autologous umbilical cord blood (UCB) in newborn infants with hypoplastic left heart syndrome (HLHS). Study Rationale and Hypotheses: The major goal of this study is to determine whether infusion of autologous UCB cells in neonates with hypoplastic left heart syndrome is feasible and safe. The rationale for the study and for the potential benefit of UCB is based upon the following hypotheses: 1. Infants with HLHS have significant neural injury evidenced from both prenatal and early antenatal brain MRI findings and infusion of UCB cells may lessen neural injury. Although the exact mechanism is unknown, UCB cell infusion may ameliorate neural injury via paracrine and anti-inflammatory effects that enhance post injury repair and may promote endogenous functional compensation of other cortical areas resulting in significant clinical improvements. 2. UCB cells may also enhance cardiac function, minimize scar formation, and reverse detrimental remodeling after cardiac injury.

NCT ID: NCT01107990 Terminated - Clinical trials for Hypoplastic Left Heart Syndrome

Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques

Start date: November 2009
Phase:
Study type: Observational

The investigators are beginning a clinical research study here at UCSF to learn more about how hearts with single ventricles work. The investigators hypothesize that myocardial strain , as measured by cardiac MRI,in patients with single ventricles differs from normal hearts. This abnormality is associated with depressed cardiac power output and impaired exercise capacity. The study will utilize cardiac magnetic resonance imaging, exercise testing, and lung function testing to study how the single ventricle heart works so that in the future the investigators can improve how the investigators care for patients with this type of congenital heart disease. The research protocol involves: Cardiac magnetic resonance imaging (MRI of the heart), exercise tests, and lung function tests. Some of these tests are routinely used to follow patients with single ventricles. Some of these tests are part of the research protocol. If you agree to participate in this study, these tests will be performed at UCSF. The results of the routine tests will be shared with your doctor. Participation will require approximately 30 additional minutes to the cardiac MRI procedure to collect the research data. The exercise tests, and lung function tests time commitment will take about two hours.

NCT ID: NCT00860327 Terminated - Tetralogy of Fallot Clinical Trials

Examining Developmental Changes in Heart Contractions of Children With Congenital Heart Defects

Start date: December 2007
Phase: N/A
Study type: Observational

Children who are born with heart defects undergo surgery when they are infants to correct the defects. However, many treatments that are used in pediatric heart patients were originally developed for adults and may not be the best option for children. This study will analyze tissue samples from newborns and infants undergoing surgery for heart defects to learn more about how a child's heart develops during the first year of life. This information may help to identify possible treatments geared specifically for the pediatric heart patient.