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Clinical Trial Summary

The effects of acute administration of non-steroidal anti-inflammatory drugs (NSAIDs) on the neuroendocrine regulation of hydro-electrolytic metabolism are not precisely known to date. Although the mechanism by which NSAIDs favor the antidiuretic action of vasopressin (AVP) in the kidney has been partially elucidated, their influence on the mechanisms responsible for regulating its secretion are less known. The interactions between NSAIDs and natriuretic peptides are also not entirely certain. The present pharmacological research study therefore aims to investigate, in a cohort of healthy subjects, the acute effects of intravenous infusion of diclofenac sodium on the neuroendocrine regulation systems of water and salt balance (i.e. the antidiuretic axis and the system of natriuretic peptides).

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05188131
Study type Interventional
Source Azienda Ospedaliera Città della Salute e della Scienza di Torino
Status Completed
Phase Phase 4
Start date October 1, 2021
Completion date December 31, 2021

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