Acute Neuroendocrine Response to Intravenous Infusion of Diclofenac Sodium

Status Completed

Clinical Trial Summary

The effects of acute administration of non-steroidal anti-inflammatory drugs (NSAIDs) on the neuroendocrine regulation of hydro-electrolytic metabolism are not precisely known to date. Although the mechanism by which NSAIDs favor the antidiuretic action of vasopressin (AVP) in the kidney has been partially elucidated, their influence on the mechanisms responsible for regulating its secretion are less known. The interactions between NSAIDs and natriuretic peptides are also not entirely certain. The present pharmacological research study therefore aims to investigate, in a cohort of healthy subjects, the acute effects of intravenous infusion of diclofenac sodium on the neuroendocrine regulation systems of water and salt balance (i.e. the antidiuretic axis and the system of natriuretic peptides).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Hypopituitarism

Clinical Trial Details

NCT number	NCT05188131
Study type	Interventional
Source	Azienda Ospedaliera Città della Salute e della Scienza di Torino
Contact
Status	Completed
Phase	Phase 4
Start date	October 1, 2021
Completion date	December 31, 2021

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