Hypoparathyroidism Clinical Trial
Official title:
Comparison of the Prognostic Value of Perioperative Parathormone Measurement and Sodium Bicarbonate Infusion Test in the Evaluation of Parathyroid Function After Total Thyroidectomy
In the study will be included patients that have undergone total thyroidectomy and do not display obvious clinical or laboratory hypoparathyroidism. On the third postoperative day and before the patient's exit from the hospital, the patient will undergo an intravenous infusion test with 35ml/m2 dilution of 8.4%(w/v) sodium bicarbonate in two minutes. Three months after the operation, if the study conditions are still met, the patient will undergo an additional parathyroid hormone (PTH) measurement and sodium bicarbonate infusion test and the parathyroid function will be evaluated again.
Each patient will undergo a thorough preoperative examination for the presence of
abnormalities in calcium, phosphate or magnesium metabolism as a consequence of a primary or
a secondary disease.
Blood samples will be taken right before the beginning of the thyroidectomy, and 20 minutes
after the end, to measure the PTH levels and to evaluate the variation rate.
On the third postoperative day and before the patient's exit from the hospital, the patient
will undergo an intravenous infusion test with 35ml/m2 dilution of 8.4%(w/v) sodium
bicarbonate in two minutes. Blood samples will be collected from a different vein at 0, 3,
5, 10, 30 and 60 minutes after infusion to measure PTH, calcium, phosphate and magnesium.
Three months after the operation, if the study conditions are still met, the patient will
undergo an additional PTH measurement and sodium bicarbonate infusion test and the
parathyroid function will be evaluated again.
In addition, the test will be performed on 50 healthy volunteers, in order to assess the
response to the test of normal individuals.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03364738 -
Safety and Efficacy Study of rhPTH(1-84) in Subjects With Hypoparathyroidism
|
Phase 3 | |
| Active, not recruiting |
NCT00856401 -
ADD-ON Study to Existing Hypoparathyroidism Studies
|
Phase 3 | |
| Completed |
NCT05043584 -
Near-infrared Autofluorescence (NIRAF)-Guided Total Thyroidectomy: Impact in Low-volume, Non-parathyroid Institutions
|
N/A | |
| Completed |
NCT03728959 -
Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism.
|
N/A | |
| Not yet recruiting |
NCT06445036 -
Tunisian Clinical Registry on Hypoparathyroidism and Pseudo-hypoparathyroidism.
|
||
| Recruiting |
NCT05556629 -
A Survey to Assess Participants' and Physicians' Knowledge, Attitudes and Behavior When Using NATPARA
|
||
| Terminated |
NCT00395538 -
Effects of PTH Replacement on Bone in Hypoparathyroidism
|
Phase 3 | |
| Completed |
NCT02910466 -
A Study of Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in Hypoparathyroidism
|
Phase 4 | |
| Completed |
NCT00001304 -
Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34
|
Phase 2 | |
| Completed |
NCT04569604 -
QoL and Cognitive Function in Patients With Hypoparathyroidism
|
||
| Completed |
NCT06449729 -
Endocrine Determinants of Renal Function in Patients With Hypoparathyroidism
|
||
| Completed |
NCT03747029 -
Serum Calcium to Phosphorous (Ca/P) Ratio in the Diagnosis of Ca-P Metabolism Disorders: a Multicentre Study
|
||
| Completed |
NCT05684029 -
Near-Infrared Autofluorescence With PTH Test Strip as an SOP of Parathyroid in Thyroid Surgery
|
||
| Not yet recruiting |
NCT06419270 -
Cardiovascular, Renal, and Skeletal Complications in Patients With Post-Surgical Hypoparathyroidism
|
||
| Completed |
NCT00473265 -
Bone Properties in Hypoparathyroidism: Effects of PTH
|
Phase 2/Phase 3 | |
| Active, not recruiting |
NCT05328076 -
Parathyroid Vascularization During Total Thyroidectomy Using Indocyanine Green Angiography
|
||
| Completed |
NCT03150108 -
Study of rhPTH(1-84) in Japanese Healthy Subjects Compared With Matched Caucasian Healthy Adult Subjects
|
Phase 1 | |
| Completed |
NCT04059380 -
Evaluation of iMmune Function in Post-surgical and AuToimmune HYpoparathyroidism (EMPATHY)
|
||
| Active, not recruiting |
NCT05965167 -
Assess Safety and Compare PK of New Oral hPTH(1-34) Tablet Formulations vs. EBP05 Tablets and Subcutaneous Forteo
|
Phase 1/Phase 2 | |
| Recruiting |
NCT02986607 -
Corticosteroid Rhythms in Hypoparathyroid Patients
|
Early Phase 1 |