Low-dose Tolvaptan for Inpatient Hyponatraemia.

Status Recruiting

Clinical Trial Summary

This is a retrospective cohort study to assess the safety and efficacy of low first dose of Tolvaptan and low or standard second dose of Tolvaptan in patients with moderate to severe hyponatraemia associated with SIADH not responding to conservative means of hyponatraemia management. Patients are treated as part of standard clinical care. There is growing evidence that treating patients with SAIDH induced hyponatraemia using a low dose of Tolvaptan with 7.5mg (below licensed lowest 15mg daily dose). This is the largest study to date and seeks to validate the efficacy and safety or this lower than approved dose of Tolvaptan in patietns who only need a first dose but also in patients who need a second low or srandard dose of Tolvaptan.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06171100
Study type	Observational
Source	King's College Hospital NHS Trust
Contact	Georgios Dimitriadis
Phone	00441698863091
Email	g.dimitriadis@nhs.net
Status	Recruiting
Phase
Start date	March 15, 2024
Completion date	December 30, 2024

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