Factors Associated With Hyponatremia Induced by High-dose Cyclophosphamide

Status Not yet recruiting

Clinical Trial Summary

Prospoctive cohort of high-dose cyclophosphamide exposed patients. With active estandardize screening of hyponatremia development in the follow up period.

Clinical Trial Description

Primary objectives

1. To identify the factors associated with the development of hyponatremia in patients receiving high-dose cyclophosphamide (2.5 grams or more).

2. Generate and validate a predictive score of developing hyponatremia high-dose cyclophosphamide.

3. To estimate the incidence of hyponatremia in patients undergoing high-dose cyclophosphamide.

Study design. Observational prospective cohort study of Patients after infusion of high-dose cyclophosphamide. Follow up period will be from cyclophosphamide infusion until one month after hospital discharge. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Hyponatremia

Clinical Trial Details

NCT number	NCT02399358
Study type	Observational
Source	Hospital Italiano de Buenos Aires
Contact	Fernando Warley, MD
Phone	+54 9 11 61541958
Email	fernando.warley@hospitalitaliano.org.ar
Status	Not yet recruiting
Phase	N/A
Start date	December 2015
Completion date	November 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06037928` - Plasma Sodium and Sodium Administration in the ICU
Recruiting	`NCT04561531` - Efficacy and Safety of Bolus Comparing With Continuous Drip of 3% NaCl in Patients With Severe Symptomatic Hyponatremia.	N/A
Terminated	`NCT02012959` - Study of the Safety and Effectiveness of SAMSCA® (Tolvaptan) in Children and Adolescents With Euvolemic or Hypervolemic Hyponatremia	Phase 3
Recruiting	`NCT02936167` - Comparison of Ringer Lactate and Isotonic Acetate Solution as Perioperative Maintenance Fluid for Children	N/A
Completed	`NCT00621348` - Maintenance Intravenous Fluids in Children	Phase 3
Terminated	`NCT03703713` - Colloid Osmotic Pressure and Osmolality in Hyponatremia
Completed	`NCT02926989` - Intravenous Fluids in Hospitalised Children	Phase 4
Terminated	`NCT02959411` - Tolvaptan for Advanced or Refractory Heart Failure	Phase 4
Completed	`NCT02573077` - An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy
Withdrawn	`NCT02667977` - Reexamining Hypotonic Intravenous Fluid Use	N/A
Terminated	`NCT01708811` - Hyponatremia and Myometrium Contractility. An Invitro Study	N/A
Completed	`NCT01456533` - Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients	N/A
Withdrawn	`NCT01326429` - Frequency and Origin of Dysnatremias in the Emergency Department	N/A
Terminated	`NCT01227512` - Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia	Phase 3
Recruiting	`NCT06013800` - Hyponatremia Volume Status Analysis by Point-of-care Ultrasound
Terminated	`NCT04020926` - Impact of Hyponatremia on Muscle Strength, Gait and Cognitive Function
Withdrawn	`NCT02442674` - A Trial of Tolvaptan in Children and Adolescent Subjects With Euvolemic and Hypervolemic Hyponatremia	Phase 3
Completed	`NCT02545101` - An Observational Study on Real-world Use and Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to SIADH	N/A
Terminated	`NCT02215148` - Pharmacokinetics and Clinical Response of Tolvaptan in Neurocritical Care Patients	N/A
Recruiting	`NCT01748331` - The Effect of Fluid Restriction in Congestive Heart Failure Complicated With Hyponatremia	N/A