Postoperative Hyponatremia - Are There Gender Differences?

Hyponatremia Clinical Trial

Official title: Postoperative Hyponatremia - Are There Gender Differences?

Status Recruiting

Clinical Trial Summary

The proposed study will focus on anesthesia and anesthesia-induced hypotension as a possible cause for postoperative fluid retention and hyponatremia, and investigate gender differences in this response.

Clinical Trial Description

30 healthy women and 30 healthy men, who are scheduled for surgery of the middle ear or parotic gland are included in the study. Within each gender group, the subjects are randomized to receive perioperative intravenous fluid regimes either based on body weight or lean body mass (LBM). The surgery lasts for at least 3 hours, the intervention period (fluid administration according to protocol) will last 10-12 hours, the study period will be 20-24 hours. Blood samples for analysis of plasma sodium, potassium, glucose and osmolality are collected preoperatively and the following morning together with analysis of urine produced during the study period. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Hyponatremia

• NCT number: NCT00636857
• Study type: Interventional
• Source: Karolinska University Hospital
• Contact: Johan Ullman, MD., PhD.
• Phone: +46 8 51 77 00 00
• Email: johan.ullman@karolinska.se
• Status: Recruiting
• Phase: N/A
• Start date: March 2008
• Completion date: December 2013