Opioid Antagonism in Hypogonadotropic Hypogonadism

Status Enrolling by invitation

Clinical Trial Summary

The goal of this study is to evaluate the effects of opioid antagonists on the hypothalamic-pituitary-gonadal axis in subjects with idiopathic hypogonadotropic hypogonadism (HH).

Clinical Trial Description

Assignment: Each study subject will serve as their own control. Delivery of Interventions: - Prior to the study visit, subjects will undergo a review of their medical history and screening laboratories. - During the inpatient study, the subjects will - Period 1: Undergo q10 min blood sampling for up to 13 hours - Receive 3 kisspeptin intravenous (IV) boluses - Receive 1 gonadotropin-releasing hormone (GnRH) IV bolus - Period 2: Undergo q10 min blood sampling for up to 13 hours - Receive a naloxone bolus followed by a naloxone infusion - Receive 3 kisspeptin IV boluses - Receive 1 GnRH IV bolus ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04975334
Study type	Interventional
Source	Massachusetts General Hospital
Contact
Status	Enrolling by invitation
Phase	Phase 2
Start date	August 31, 2024
Completion date	May 31, 2025

View Details

See also
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